Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia
文献类型：期刊论文
| 作者 | He Li; Zhou Gang; He Yuling; Xie Luokun; Xiong Jie; Lei Hao; Wei Li; Hu Chunsong; Liu Junyan; Jiang Mingshen |
| 刊名 | JOURNAL OF IMMUNOLOGY
 |
| 出版日期 | 2006-09-15 |
| 卷号 | 177期号:6页码:3644-3656 |
| 英文摘要 | What mechanism that determines microglia accomplishing destructive or constructive role in CNS remains nebulous. We report here that intracranial priming and rechallenging with Toxoplasma gondii in mice elicit neurotoxic CCR9(+)Irg1(+) (immunoresponsive gene 1) microglia, which render resistance to apoptosis and produce a high level of TNF-alpha; priming and rechallenging with lymphocytic choriomeningitis virus elicit neurosupportive CXCR3(+)Irg1(-) microglia, which are sensitive to apoptosis and produce a high level of IL-10 and TGF-beta. Administration of CCR9 and/or Irg1 small interfering RNA alters the frequency and functional profiles of neurotoxic CCR9(+)Irg1(+) and neurosupportive CXCR3(+)Irg1(+) microglia in vivo. Moreover, by using a series of different neurotropic pathogens, including intracellular parasites, chronic virus, bacteria, toxic substances, and CNS injury to intracranially prime and subsequent rechallenge mice, the bi-directional elicitation of microglia has been confirmed as neurotoxic CCR9(+)Irg1(+) and neurosupportive CXCR3(+)Irg1(+) cells in these mouse models. These data suggest that there exist two different types of microglia, providing with a novel insight into microglial involvement in neurodegenerative and neuroinflammatory pathogenesis such as Alzheimer's disease and AIDS dementia. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Immunology |
| 研究领域[WOS] | Immunology |
| 关键词[WOS] | CENTRAL-NERVOUS-SYSTEM ; T-CELLS ; DISEASE PATHOGENESIS ; ACTIVATED MICROGLIA ; PERIVASCULAR CELLS ; IMMUNE-RESPONSES ; VIRAL-INFECTION ; BRAIN MICROGLIA ; DENDRITIC CELLS ; CUTTING EDGE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000240475300017 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4670]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Wuhan Univ, Sch Med, Dept Immunol, Wuhan 430071, Peoples R China 2.Wuhan Univ, Sch Med, Dept Parasitol, Inst Allegy & Immunerealted Dis, Wuhan 430071, Peoples R China 3.Wuhan Univ, Sch Med, Neurosci Lab, Wuhan 430071, Peoples R China 4.Wuhan Univ, Sch Med, Lab Allergy & Clin Immunol, Med Res Ctr, Wuhan 430071, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Mol Biol & Neurosci, Inst Biochem & Cell Biol, Shanghai, Peoples R China 6.Chinese Acad Sci, Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China 7.Chinese Acad Sci, Inst Chem, Key Lab Colloid Interface Sci & Chem Thermodynam, Beijing 100080, Peoples R China 8.Anhui Med Univ, Coll Basic Med Sci, Dept Immunol, Hefei, Peoples R China 9.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Immunol, Wuhan 430074, Peoples R China 10.Fourth Mil Med Univ, Dept Immunol, Xian 710032, Peoples R China |
| 推荐引用方式 GB/T 7714 | He Li,Zhou Gang,He Yuling,et al. Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia[J]. JOURNAL OF IMMUNOLOGY,2006,177(6):3644-3656. |
| APA | He Li.,Zhou Gang.,He Yuling.,Xie Luokun.,Xiong Jie.,...&Tan Jinquan.(2006).Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia.JOURNAL OF IMMUNOLOGY,177(6),3644-3656. |
| MLA | He Li,et al."Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia".JOURNAL OF IMMUNOLOGY 177.6(2006):3644-3656. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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