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Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives
文献类型：期刊论文
| 作者 | Lu, ZB; Nie, GJ; Belton, PS; Tang, HR; Zhao, BL |
| 刊名 | NEUROCHEMISTRY INTERNATIONAL
 |
| 出版日期 | 2006-03-01 |
| 卷号 | 48期号:4页码:263-274 |
| 关键词 | free radicals antioxidant ESR hydrophobicity partition coefficient gallic acid oxidative stress reactive oxygen species glutathione apoptosis |
| 英文摘要 | Gallic acid and its derivatives are a group of naturally occurring polyphenol antioxidants which have recently been shown to have potential healthy effects. In order to understand the relationship between the structures of gallic acid derivatives, their antioxidant activities, and neuroprotective effects, we examined their free radical scavenging effects in liposome and anti-apoptotic activities in human SH-SY5Y cell induced by 6-hydrodopamine autooxidation. It was found that these polyphenol antioxidants exhibited different hydrophobicity and could cross through the liposome membrane to react with 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical in a time and dose-dependent manner. At the same time, the structure-antioxidant activity relationship of gallic acid derivatives on scavenging DPPH free radical in the liposome was also analyzed based on theoretical investigations. Analysis of cell apoptosis, intracellular GSH levels, production of ROS and the influx of Ca2+ indicated that the protective effects of gallic acid derivatives in cell systems under oxidative stress depend on both their antioxidant capacities and hydrophobicity. However, the neuroprotective effects of gallic acid derivatives seem to depend more on their molecular polarities rather than antioxidant activities in the human SH-SY5Y cell line. In conclusion, these results reveal that compounds with high antioxidant activity and appropriate hydrophobicity are generally more effective in preventing the injury of oxidative stress in neurodegenerative diseases. (C) 2005 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Neurosciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 关键词[WOS] | RAPID COLORIMETRIC ASSAY ; OXIDATIVE STRESS ; PHENOLIC ANTIOXIDANTS ; PARKINSONS-DISEASE ; FREE-RADICALS ; CELL-DEATH ; SELECTIVE-INHIBITION ; NEUROBLASTOMA-CELLS ; INDUCED APOPTOSIS ; TEA CATECHINS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000235597000003 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4692]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Inst Phys & Math, State Key Lab Magnet Resonance & Mol & Atom Phys, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Inst Biophys, State Key Lab Brain, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Biophys, Recognit Lab, Beijing 100101, Peoples R China 4.McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Dept Physiol, Montreal, PQ H3T 1E2, Canada 5.Univ E Anglia, Sch Chem Sci & Pharm, Norwich NR4 7TJ, Norfolk, England 6.Chinese Acad Sci, Grad Sch, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, ZB,Nie, GJ,Belton, PS,et al. Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives[J]. NEUROCHEMISTRY INTERNATIONAL,2006,48(4):263-274. |
| APA | Lu, ZB,Nie, GJ,Belton, PS,Tang, HR,&Zhao, BL.(2006).Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives.NEUROCHEMISTRY INTERNATIONAL,48(4),263-274. |
| MLA | Lu, ZB,et al."Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives".NEUROCHEMISTRY INTERNATIONAL 48.4(2006):263-274. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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