Synthesis, characterization and relaxivity of dimeric DTPA-gadonium (III) complexes with long chain alkyl esters of L-lysine
文献类型：期刊论文
| 作者 | Yu, KC; Li, LY; Wan, FX; Zhou, JL; Ding, SW; Ye, CH |
| 刊名 | SPECTROSCOPY AND SPECTRAL ANALYSIS
 |
| 出版日期 | 2006-04-01 |
| 卷号 | 26期号:4页码:670-673 |
| 关键词 | MRI dimeric contrast agent ester of L-lysine amphiphilicity gadolinium complex longitudinal relaxivity(R(1)) |
| 英文摘要 | To look for new MRI (magnetic resonance imaging) contrast agents with higher relaxivity as well as liver-selecsivity, four novel ester-amino ligands were synthesized by bis-acylation of octadecanyl, hexadecanyl, tetradecanyl and dedecanyl L-lysine with diethylenetriaminepentaacetic acid mono-anhydride (DTPA-MA), respectively. The corresponding dimeric Gd(M) complexes were gained by the reaction of these ligands with GdCl(3) center dot 6H(2)O. All ligands and complexes were characterized by FTIR, (1)H NMR and elemental analysis. The longitudinal relaxation time (T(1)) was measured, and relevant longitudinal relaxivity (R(1)) of these neatral binuclear Gd (III) complexes is: 6.48, 6.02, 5.76 and 5.68 L . mmol(-1) . s(-1), respectively, and all are higher than that of Gd-DTPA (4.98 L . mmol(-1) . s(-1)) (300 MHz). |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Spectroscopy |
| 研究领域[WOS] | Spectroscopy |
| 关键词[WOS] | MAGNETIC-RESONANCE ; CONTRAST AGENTS ; NMR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000237163500021 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4694]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Dept Chem, Wuhan 430074, Peoples R China 2.Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 80424, Taiwan 3.Natl Sun Yat Sen Univ, Ctr Nanosci & Nanotechnol, Kaohsiung 80424, Taiwan 4.Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, KC,Li, LY,Wan, FX,et al. Synthesis, characterization and relaxivity of dimeric DTPA-gadonium (III) complexes with long chain alkyl esters of L-lysine[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS,2006,26(4):670-673. |
| APA | Yu, KC,Li, LY,Wan, FX,Zhou, JL,Ding, SW,&Ye, CH.(2006).Synthesis, characterization and relaxivity of dimeric DTPA-gadonium (III) complexes with long chain alkyl esters of L-lysine.SPECTROSCOPY AND SPECTRAL ANALYSIS,26(4),670-673. |
| MLA | Yu, KC,et al."Synthesis, characterization and relaxivity of dimeric DTPA-gadonium (III) complexes with long chain alkyl esters of L-lysine".SPECTROSCOPY AND SPECTRAL ANALYSIS 26.4(2006):670-673. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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