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Studies on a new carrier of trimethylsilyl-modified mesoporous material for controlled drug delivery
文献类型：期刊论文
| 作者 | Tang, Qunli; Xu, Yao; Wu, Dong; Sun, Yuhan; Wang, Jiqing; Xu, Jun; Deng, Feng |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2006-08-10 |
| 卷号 | 114期号:1页码:41-46 |
| 关键词 | MCM-41 ibuprofen trimethylsilyl (TMS) modification controlled drug delivery |
| 英文摘要 | To better control drug delivery rate, a simple and effective approach has been developed for controlled drug delivery carrier system through one-step surface modification of the ibuprofen-impregnated silica MCM-41 with 1, 1, 1, 3, 3, 3-hexamethyldisilazane (HMDS). The Si-29 MAS NMR characterization demonstrated that different contents of trimethylsityl (TMS) groups were successfully grafted onto the samples modified with different silylation times. The results obtained from in vitro tests exhibited that the introduction of TMS groups greatly retarded the ibuprofen release rate. Even after in vitro test for 48 h, only 75% of the impregnated ibuprofen could be released from the modified sample with TMS groups content of 14.5% (related to the total silicon atoms). However, the release of ibuprofen could be completed just after about I h from the pure silica MCM-41 under the same release conditions. Furthermore, the release rate of ibuprofen could be well modulated by changing the grafted content of TMS groups, and was found to decrease with increasing grafted amount of TMS groups. (c) 2006 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine |
| 类目[WOS] | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Chemistry ; Pharmacology & Pharmacy |
| 关键词[WOS] | MCM-41 MATERIALS ; SILICA-GEL ; RELEASE ; SBA-15 ; FUNCTIONALIZATION ; ADSORPTION ; MOLECULES ; SURFACE ; SPHERES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000240052500003 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4787]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Inst Coal Chem, State Key Lab Coal Convers, Taiyuan 030001, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Qunli,Xu, Yao,Wu, Dong,et al. Studies on a new carrier of trimethylsilyl-modified mesoporous material for controlled drug delivery[J]. JOURNAL OF CONTROLLED RELEASE,2006,114(1):41-46. |
| APA | Tang, Qunli.,Xu, Yao.,Wu, Dong.,Sun, Yuhan.,Wang, Jiqing.,...&Deng, Feng.(2006).Studies on a new carrier of trimethylsilyl-modified mesoporous material for controlled drug delivery.JOURNAL OF CONTROLLED RELEASE,114(1),41-46. |
| MLA | Tang, Qunli,et al."Studies on a new carrier of trimethylsilyl-modified mesoporous material for controlled drug delivery".JOURNAL OF CONTROLLED RELEASE 114.1(2006):41-46. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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