Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied ex vivo by high resolution H-1 NMR spectroscopy
文献类型：期刊论文
| 作者 | Gao, Hongchang; Xiang, Yun; Sun, Ninglei; Zhu, Hang; Wang, Yaqiang; Liu, Maili; Ma, Yuanye; Lei, Hao |
| 刊名 | NEUROCHEMISTRY INTERNATIONAL
 |
| 出版日期 | 2007 |
| 卷号 | 50期号:2页码:386-394 |
| 关键词 | morphine H-1 NMR rat drug dependence metabolism neurotransmitter |
| 英文摘要 | Ex vivo H-1 NMR spectroscopy was used to measure changes in the concentrations of cerebral metabolites in the prefrontal cortex (PFC) and hippocampus of rats subjected to repeated morphine treatment known to cause tolerance/dependence. The results show that repeated morphine exposure induces significant changes in the concentrations of a number of cerebral metabolites, and such changes are region specific. After 10 days of repeated morphine treatment, the concentration of gamma-aminobutyric acid (GABA) increased significantly in the PFC (20 +/- 11%), but decreased in the hippocampus (-31 +/- 12%), compared to control. In contrast, the glutamate (Glu) concentrations in both the PFC (-15 +/- 8%) and hippocampus (-13 +/- 4%) decreased significantly. Significant changes were also observed in the concentrations of hippocampal glutamine (Gin), myo-inositol, taurine, and N-acetyl aspartate. These morphine-induced changes were reversed during a subsequent 5-day withdrawal period. It is suggested that the observed concentration changes for Glu, Gin and GABA are most likely the result of a shift in the steady-state equilibrium of the Gln-Glu-GABA metabolic cycle. Changes in the metabolism of this neurotransmitter system might be part of the adaptive measures taken by the central nervous system in response to repeated morphine exposure and subsequent withdrawal. (c) 2006 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Neurosciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 关键词[WOS] | GAMMA-AMINOBUTYRIC-ACID ; VENTRAL TEGMENTAL AREA ; MAGNETIC-RESONANCE-SPECTROSCOPY ; CEREBRAL GLUCOSE-UTILIZATION ; ABSTINENT COCAINE USERS ; NEUROCHEMICAL PROFILE ; NUCLEUS-ACCUMBENS ; GLUTAMATE RELEASE ; DOPAMINE SYSTEM ; DOWN-REGULATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000244158400014 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4832]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Lab Primate Cognit Neurosci, Kunming 650223, Peoples R China 4.Jianghan Univ, Med & Life Sci Sch, Wuhan 430056, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Hongchang,Xiang, Yun,Sun, Ninglei,et al. Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied ex vivo by high resolution H-1 NMR spectroscopy[J]. NEUROCHEMISTRY INTERNATIONAL,2007,50(2):386-394. |
| APA | Gao, Hongchang.,Xiang, Yun.,Sun, Ninglei.,Zhu, Hang.,Wang, Yaqiang.,...&Lei, Hao.(2007).Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied ex vivo by high resolution H-1 NMR spectroscopy.NEUROCHEMISTRY INTERNATIONAL,50(2),386-394. |
| MLA | Gao, Hongchang,et al."Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied ex vivo by high resolution H-1 NMR spectroscopy".NEUROCHEMISTRY INTERNATIONAL 50.2(2007):386-394. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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