Bilateral common carotid artery occlusion induced brain lesions in rats: A longitudinal diffusion tensor imaging study
文献类型：期刊论文
| 作者 | Wang, Xuxia; Lin, Fuchun; Gao, Yunling; Lei, Hao |
| 刊名 | MAGNETIC RESONANCE IMAGING
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 33期号:5页码:551-558 |
| 关键词 | Diffusion tensor imaging Axial diffusivity Radial diffusivity Demyelination Axon damage |
| 英文摘要 | Bilateral common carotid artery occlusion (BCCAO) has been widely used to reproduce the white matter (WM) and gray matter (GM) damage associated with chronic cerebral hypoperfusion (CCH). This study investigated whether diffusion tensor imaging (DTI) could be used at the early stages of disease to assess brain damage induced by BCCAO. To this end, DTI, together with histological methods, was used to evaluate the progression of WM lesions and GM neurodegeneration following BCCAO. The DTI was sufficiently sensitive to detect WM abnormalities in selected regions of the brain at 4 weeks after BCCAO. These abnormalities may indicate damage to the myelin and axons in the optic nerve (ON) and optic tract (OT). Our longitudinal results showed that DTI could be used to detect abnormalities of the WM and GM in select regions of the brain as early as 2 days after ligation. The DTI parameter patterns of change were region-specific throughout the detection time course. Lesions of the external capsule (EC) and periventricular hypothalamic nucleus (Pe) have not been thoroughly studied before. We found that the EC and Pe were both vulnerable to BCCAO and that the associated lesions could be detected using DTI. The current study demonstrated that in vivo DTI could potentially be used to measure WM damage evolution in a BCCAO rat model as well as early brain injury following CCH. (C) 2015 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | CHRONIC CEREBRAL HYPOPERFUSION ; WHITE-MATTER DAMAGE ; BLOOD-FLOW ; COGNITIVE IMPAIRMENT ; HUNTINGTONS-DISEASE ; CORPUS-CALLOSUM ; AXONAL DAMAGE ; MODEL ; PERMANENT ; DEMYELINATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000354831500007 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4736]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | Chinese Acad Sci, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xuxia,Lin, Fuchun,Gao, Yunling,et al. Bilateral common carotid artery occlusion induced brain lesions in rats: A longitudinal diffusion tensor imaging study[J]. MAGNETIC RESONANCE IMAGING,2015,33(5):551-558. |
| APA | Wang, Xuxia,Lin, Fuchun,Gao, Yunling,&Lei, Hao.(2015).Bilateral common carotid artery occlusion induced brain lesions in rats: A longitudinal diffusion tensor imaging study.MAGNETIC RESONANCE IMAGING,33(5),551-558. |
| MLA | Wang, Xuxia,et al."Bilateral common carotid artery occlusion induced brain lesions in rats: A longitudinal diffusion tensor imaging study".MAGNETIC RESONANCE IMAGING 33.5(2015):551-558. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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