Aberrant corticostriatal functional circuits in adolescents with Internet addiction disorder
文献类型：期刊论文
| 作者 | Lin, Fuchun1; Zhou, Yan2; Du, Yasong3; Zhao, Zhimin3; Qin, Lindi2; Xu, Jianrong2; Lei, Hao1 |
| 刊名 | FRONTIERS IN HUMAN NEUROSCIENCE
 |
| 出版日期 | 2015-06-16 |
| 卷号 | 9 |
| 关键词 | corticostriatal circuits functional connectivity internet addiction disorder neuropsychological measures resting-state fMRI |
| 英文摘要 | Abnormal structure and function in the striatum and prefrontal cortex (PFC) have been revealed in Internet addiction disorder (IAD). However, little is known about alterations of corticostriatal functional circuits in IAD. The aim of this study was to investigate the integrity of corticostriatal functional circuits and their relations to neuropsychological measures in IAD by resting-state functional connectivity (FC). Fourteen IAD adolescents and 15 healthy controls underwent resting-state fMRI scans. Using six predefined bilateral striatal regions-of-interest, voxel-wise correlation maps were computed and compared between groups. Relationships between alterations of corticostriatal connectivity and clinical measurements were examined in the IAD group. Compared to controls, IAD subjects exhibited reduced connectivity between the inferior ventral striatum and bilateral caudate head, subgenual anterior cingulate cortex (ACC), and posterior cingulate cortex, and between the superior ventral striatum and bilateral dorsal/rostral ACC, ventral anterior thalamus, and putamen/pallidum/insula/inferior frontal gyrus (IFG), and between the dorsal caudate and dorsal/rostral ACC, thalamus, and IFG, and between the left ventral rostral putamen and right IFG. IAD subjects also showed increased connectivity between the left dorsal caudal putamen and bilateral caudal cigulate motor area. Moreover, altered cotricostriatal functional circuits were significantly correlated with neuropsychological measures. This study directly provides evidence that IAD is associated with alterations of corticostriatal functional circuits involved in the affective and motivation processing, and cognitive control. These findings emphasize that functional connections in the corticostriatal circuits are modulated by affective/motivational/cognitive states and further suggest that IAD may have abnormalities of such modulation in this network. |
| WOS标题词 | Science & Technology ; Social Sciences ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences ; Psychology |
| 研究领域[WOS] | Neurosciences & Neurology ; Psychology |
| 关键词[WOS] | OBSESSIVE-COMPULSIVE DISORDER ; POSITRON-EMISSION-TOMOGRAPHY ; SUBGENUAL CINGULATE CORTEX ; BASAL GANGLIA ; GAMING DISORDER ; RESPONSE-INHIBITION ; UNIVERSITY-STUDENTS ; CHINESE ADOLESCENTS ; ALCOHOL DEPENDENCE ; PREFRONTAL CORTEX |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356438700001 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4756]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Chinese Acad Sci, Natl Ctr Magnet Resonance Wuhan, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Jiao Tong Univ, RenJi Hosp, Sch Med, Dept Radiol, Shanghai 200030, Peoples R China 3.Jiao Tong Univ, Shanghai Mental Hlth Ctr, Dept Child & Adolescent Psychiat, Shanghai 200030, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Fuchun,Zhou, Yan,Du, Yasong,et al. Aberrant corticostriatal functional circuits in adolescents with Internet addiction disorder[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2015,9. |
| APA | Lin, Fuchun.,Zhou, Yan.,Du, Yasong.,Zhao, Zhimin.,Qin, Lindi.,...&Lei, Hao.(2015).Aberrant corticostriatal functional circuits in adolescents with Internet addiction disorder.FRONTIERS IN HUMAN NEUROSCIENCE,9. |
| MLA | Lin, Fuchun,et al."Aberrant corticostriatal functional circuits in adolescents with Internet addiction disorder".FRONTIERS IN HUMAN NEUROSCIENCE 9(2015). |
入库方式： OAI收割
来源：武汉物理与数学研究所
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