Metallothionein and superoxide dismutase responses to sublethal cadmium exposure in the clam Mactra veneriformis
文献类型：期刊论文
| 作者 | Fang, Yan2; Yang, Hongsheng1 ; Wang, Tianming2; Liu, Baozhong; Zhao, Heling2; Chen, Muyan
|
| 刊名 | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
 |
| 出版日期 | 2010-04-01 |
| 卷号 | 151期号:3页码:325-333 |
| 关键词 | Cadmium Mactra veneriformis Metallothionein mRNA expression Superoxide dismutase |
| 英文摘要 | The objective of this study was to identify the relationship between cadmium (Cd) and stress responses in the clam Mactra veneriformis. Metallothionein (MT) and Cu-Zn superoxide dismutase (SOD) cDNAs from the clam were isolated and characterized. The full-length cDNA of MvMT and MvSOD contained 830 and 689 nucleotides encoding 59 and 159 amino acids, respectively. Multiple alignments indicated that deduced amino acid sequences of MvMT and MvSOD shared high homology with MT and SOD sequences of other mollusks. Clams were exposed to 0, 50, 100, and 200 mu g/L Cd for 21 days. The mRNA transcripts of the two genes, MT protein content and SOD activity in the digestive gland were examined. Cd treatment significantly elevated MvMT and MvSOD mRNA expression in a dose-dependent manner and MT protein level in a dose-and time-dependent manner. SOD activity significantly increased at the start of CA exposure, then decreased and finally returned to the normal level. These results indicate that MT and SOD play an important role in maintaining cellular metabolism homeostasis and protecting M. veneriformis from Cd toxicity. MT and SOD could be used as biomarkers; of CA pollution in aquatic environment for the studied species. (C) 2009 Elsevier Inc. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000275627400009 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/32686]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Shandong, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Yan,Yang, Hongsheng,Wang, Tianming,et al. Metallothionein and superoxide dismutase responses to sublethal cadmium exposure in the clam Mactra veneriformis[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,2010,151(3):325-333. |
| APA | Fang, Yan,Yang, Hongsheng,Wang, Tianming,Liu, Baozhong,Zhao, Heling,&Chen, Muyan.(2010).Metallothionein and superoxide dismutase responses to sublethal cadmium exposure in the clam Mactra veneriformis.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,151(3),325-333. |
| MLA | Fang, Yan,et al."Metallothionein and superoxide dismutase responses to sublethal cadmium exposure in the clam Mactra veneriformis".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 151.3(2010):325-333. |
入库方式： OAI收割
来源：海洋研究所
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