Accumulation and oxidative stress biomarkers in Japanese flounder larvae and juveniles under chronic cadmium exposure
文献类型：期刊论文
| 作者 | Cao, Liang1,2; Huang, Wei1,2; Liu, Jinhu1,2; Yin, Xuebo1; Dou, Shuozeng1 |
| 刊名 | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
 |
| 出版日期 | 2010-04-01 |
| 卷号 | 151期号:3页码:386-392 |
| 关键词 | Oxidative stress Antioxidants and LPO Toxicity Paralichthys olivaceus |
| 英文摘要 | This study investigated how Cd exposure affected oxidative biomarkers in Japanese flounder, Paralichthys olivaceus, at early life stages (ELS). Fish were exposed to waterborne Cd (0-48 mu g L(-1)) from embryonic to juvenile stages for 80 days. Growth, Cd accumulation, activities of superoxide dismutase (SOD, EC 1.15.1.1), catalase (CAT, EC 1.11.1.6), glutathione S-transferase (GST, EC 2.5.1.18), and levels of glutathione (GSH) and lipid peroxidation (LPO) were investigated at three developmental stages. Flounder growth decreased and Cd accumulation increased with increasing Cd concentration. In metamorphosing larvae, CAT and SOD activities were inhibited and GSH level was elevated, while LPO was enhanced by increasing Cd concentrations. CAT and GST activities of settling larvae were inhibited but GSH level was elevated at high Cd concentrations. In juveniles, SOD activity and LPO level were increased but GST activity was inhibited as Cd concentration increased. Antioxidants in flounder at ELS were able to develop ductile responses to defend against oxidative stress, but LPO fatally occurred due to Cd exposure. These biochemical parameters could be used as effective oxidative biomarkers for evaluating Cd contamination and toxicity in marine environments: CAT, SOD, GSH, and LPO for metamorphosing stage: CAT, GSH, and GST for settling stage; and SOD, GST, and LPO for juvenile stage. (C) 2010 Elsevier Inc. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000275627400016 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/32703]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Liang,Huang, Wei,Liu, Jinhu,et al. Accumulation and oxidative stress biomarkers in Japanese flounder larvae and juveniles under chronic cadmium exposure[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,2010,151(3):386-392. |
| APA | Cao, Liang,Huang, Wei,Liu, Jinhu,Yin, Xuebo,&Dou, Shuozeng.(2010).Accumulation and oxidative stress biomarkers in Japanese flounder larvae and juveniles under chronic cadmium exposure.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,151(3),386-392. |
| MLA | Cao, Liang,et al."Accumulation and oxidative stress biomarkers in Japanese flounder larvae and juveniles under chronic cadmium exposure".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 151.3(2010):386-392. |
入库方式： OAI收割
来源：海洋研究所
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