Chemical constituents of the red alga Laurencia tristicha
文献类型：期刊论文
| 作者 | Sun, Jie4; Shi, Da-Yong3,4; Li, Shuai1,2; Wang, Su-Juan1,2; Han, Li-Jun3; Fan, Xiao3; Yang, Yong-Chun1,2; Shi, Jian-Gong1,2 |
| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 出版日期 | 2007 |
| 卷号 | 9期号:8页码:725-734 |
| 关键词 | red alga Laurencia tristicha chemical constituents |
| 英文摘要 | Six new sesquiterpenes, 10-hydroxy-epiaplysin (1), 10-hydroxy-aplysin (2), 10-hydroxy-debromoepiaplysin (3), aplysin-9-ene (4), epiaplysinol (5) and debromoepiaplysinol (6), together with 13 known compounds (7-19), have been isolated from the red alga Laurencia tristicha. The structures of 1-6 were determined by spectroscopic methods including IR, EI-MS, HREI-MS, and 1D and 2D NMR techniques. All compounds were obtained from this species for the first time and were tested for cytotoxic activities against several human cancer cell lines including lung adenocarcinoma (A549), stomach cancer (BGC-823), hepatoma (Bel 7402), colon cancer (HCT-8) and HeLa cell lines. Compound 6 showed selective cytotoxicity against HeLa cell line with IC50 15.5 mu M, cholest-5-en-3 beta,7 alpha-diol (14) was toxic to all tested cell lines with IC50 values of 16.8, 5.1, 0.5, 0.5, and 0.3 mu M, respectively, and other compounds were inactive (IC50 > 10 mu g/ml). |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000253300500006 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/32597]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 2.Pekeng Union Med Coll, Key Lab Bioact Substances & Resources Unilizat Ch, Minist Educ, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 4.Ludong Univ, Coll Life Sci, Yantai 264025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Jie,Shi, Da-Yong,Li, Shuai,et al. Chemical constituents of the red alga Laurencia tristicha[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2007,9(8):725-734. |
| APA | Sun, Jie.,Shi, Da-Yong.,Li, Shuai.,Wang, Su-Juan.,Han, Li-Jun.,...&Shi, Jian-Gong.(2007).Chemical constituents of the red alga Laurencia tristicha.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,9(8),725-734. |
| MLA | Sun, Jie,et al."Chemical constituents of the red alga Laurencia tristicha".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 9.8(2007):725-734. |
入库方式： OAI收割
来源：海洋研究所
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