alpha-Glucosidase Inhibition and the In Vivo Hypoglycemic Effect of Butyl-isobutyl-phthalate derived from the Laminaria japonica Rhizoid
文献类型：期刊论文
| 作者 | Bu, Tong1; Liu, Ming1; Zheng, Lanhong1; Guo, Yuewei2; Lin, Xiukun1 |
| 刊名 | PHYTOTHERAPY RESEARCH
 |
| 出版日期 | 2010-11-01 |
| 卷号 | 24期号:11页码:1588-1591 |
| 关键词 | butyl-isobutyl-phthalate alpha-glucosidase hypoglycemic effect Laminaria japonica rhizoid |
| 英文摘要 | The rhizoid of Laminaria japonica is widely used in Chinese medicine as a treatment for diabetes. Therefore, a bioactivity-tailored isolation and detailed chemical characterization was used to identify the antidiabetes compounds found in the L. japonica rhizoid. Liquid chromatography/mass spectrometry (LC/MS), proton NMR and carbon NMR spectra analyses demonstrated that the active compound was butyl-isobutyl-phthalate (BIP). BIP demonstrated a significant concentration-dependent, non-competitive inhibitory activity against alpha-glucosidase in vitro, with an IC(50) of 38 mu M. In vivo, the ethyl acetate fraction (EAF) and purified BIP displayed a significant hypoglycemic effect in streptozocin-induced diabetic mice. The present study indicates BIP could be considered as an alpha-glucosidase inhibitor and developed as an important antidiabetes agent for type II diabetes therapy. Copyright (C) 2010 John Wiley & Sons, Ltd. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000283794300002 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/32771]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bu, Tong,Liu, Ming,Zheng, Lanhong,et al. alpha-Glucosidase Inhibition and the In Vivo Hypoglycemic Effect of Butyl-isobutyl-phthalate derived from the Laminaria japonica Rhizoid[J]. PHYTOTHERAPY RESEARCH,2010,24(11):1588-1591. |
| APA | Bu, Tong,Liu, Ming,Zheng, Lanhong,Guo, Yuewei,&Lin, Xiukun.(2010).alpha-Glucosidase Inhibition and the In Vivo Hypoglycemic Effect of Butyl-isobutyl-phthalate derived from the Laminaria japonica Rhizoid.PHYTOTHERAPY RESEARCH,24(11),1588-1591. |
| MLA | Bu, Tong,et al."alpha-Glucosidase Inhibition and the In Vivo Hypoglycemic Effect of Butyl-isobutyl-phthalate derived from the Laminaria japonica Rhizoid".PHYTOTHERAPY RESEARCH 24.11(2010):1588-1591. |
入库方式： OAI收割
来源：海洋研究所
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