Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: Implications for the toxicology mechanism of some persistent organic pollutants (POPs)
文献类型：期刊论文
| 作者 | Zhou, Hailong1,2,3,4,5; Qu, Ying1,3,4; Wu, Huifeng1,3; Liao, Chunyang1,3; Zheng, Jiping2; Diao, Xiaoping2; Xue, Qinzhao1,3 |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2010 |
| 卷号 | 78期号:2页码:193-205 |
| 关键词 | AhR pathway Non-synonymous nucleotide substitutions (d(N)) Synonymous nucleotide substitutions (d(S)) Persistent organic pollutants (POPs) |
| 英文摘要 | Phylogenetic analysis of AhR pathway genes and their evolutionary rate variations were studied on aquatic animals. The gene sequences for the proteins involved in this pathway were obtained from four major phylogenetic groups, including bivalvia, amphibian, teleostei and mammalia. These genes were distributed under four major steps of toxicology regulation: formation of cytosolic complex, translocation of AhR, heterodimerization of AhR and induction of CYP1A. The NJ, MP, and ML algorithm were used on protein coding DNA sequences to deduce the evolutionary relationship for the respective AhR pathway gene among different aquatic animals. The rate of non-synonymous nucleotide substitutions per non-synonymous site (d(N)) and synonymous nucleotide substitutions per synonymous site (d(S)) were calculated for different clade of the respective phylogenetic tree for each AhR pathway gene. The phylogenetic analysis suggests that evolutionary pattern of AhR pathway genes in aquatic animals is characterized mainly through gene duplication events or alterative splicing. The d(N) values indicate that all AhR pathway genes are well conserved in aquatic animals, except for CYP1A gene. Furthermore, compare with other aquatic animals, the d(N) value indicates that AhR pathway genes of fish are less conserved, and these genes likely go through an adaptive evolution within aquatic animals. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000272888200017 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/32835]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China 2.Hainan Univ, Coll Agr, Dept Biotechnol, Haikou 570228, Peoples R China 3.Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Hailong,Qu, Ying,Wu, Huifeng,et al. Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: Implications for the toxicology mechanism of some persistent organic pollutants (POPs)[J]. CHEMOSPHERE,2010,78(2):193-205. |
| APA | Zhou, Hailong.,Qu, Ying.,Wu, Huifeng.,Liao, Chunyang.,Zheng, Jiping.,...&Xue, Qinzhao.(2010).Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: Implications for the toxicology mechanism of some persistent organic pollutants (POPs).CHEMOSPHERE,78(2),193-205. |
| MLA | Zhou, Hailong,et al."Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: Implications for the toxicology mechanism of some persistent organic pollutants (POPs)".CHEMOSPHERE 78.2(2010):193-205. |
入库方式： OAI收割
来源：海洋研究所
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