Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor
文献类型：期刊论文
| 作者 | Shi Dayong1; Li Xiaohong2; Li Jing1 ; Guo Shuju1; Su Hua1; Fan Xiao1
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| 刊名 | CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
 |
| 出版日期 | 2010 |
| 卷号 | 28期号:1页码:96-98 |
| 关键词 | thrombin inhibitor antithrombotic effect bromophenol derivative |
| 英文摘要 | Thrombin, the ultimate proteinase of the coagulation cascade, is an attractive target for the treatment of a variety of cardiovascular diseases. A bromophenol derivative named (+)-3-(2,3-dibromo-4, 5-dihydroxy-phenyl)-4-bromo-5,6-dihydroxy-1,3-dihydroiso-benzofuran 1, isolated from the brown alga Leathesia nana exhibited significant thrombin inhibitory activity. In this study, we investigated the inhibition of human thrombin in vitro with this bromophenol derivative, and its antithrombotic efficacy in vivo using the arteriovenous shunt model and the ferric chloride-induced arterial thrombosis model in rats. The results show that the bromophenol derivative is a potential inhibitor of thrombin (IC(50) = 1.03 nmol/L). In antithrombotic experiments in vivo, the bromophenol derivative also shows good effect comparing with the control group. These data indicate that the bromophenol derivative is a potential drug for prophylaxis and the treatment of thrombotic diseases. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000275654100013 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/32889]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Qingdao Municipal Hosp, Qingdao 266011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi Dayong,Li Xiaohong,Li Jing,et al. Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2010,28(1):96-98. |
| APA | Shi Dayong,Li Xiaohong,Li Jing,Guo Shuju,Su Hua,&Fan Xiao.(2010).Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,28(1),96-98. |
| MLA | Shi Dayong,et al."Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 28.1(2010):96-98. |
入库方式： OAI收割
来源：海洋研究所
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