Inhibition of the Acquisition of Conditioned Place Aversion by Dopaminergic Lesions of the Central Nucleus of the Amygdala in Morphine-Treated Rats
文献类型：期刊论文
| 作者 | Xu, W.1,2; Li, Y. H.1; Tan, B. P.1; Luo, X. J.1; Xiao, L.1; Zheng, X. G.1; Yang, X. Y.1; Sui, N.1 |
| 刊名 | PHYSIOLOGICAL RESEARCH
 |
| 出版日期 | 2012 |
| 卷号 | 61期号:4页码:437-442 |
| 关键词 | Conditioned place aversion Central nucleus of amygdala Dopamine 6-OHDA |
| ISSN号 | 0862-8408 |
| 产权排序 | 1 |
| 通讯作者 | Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Mental Hlth Key Lab, POB 1603, Beijing 100101, Peoples R China. |
| 英文摘要 | The negative affective state of opiate abstinence plays an important role in craving and relapse to compulsive drug use. The dopamine system participates in the reward effects of opiate use and the aversive effect of opiate abstinence. The amygdala is an essential neural substrate for associative learning of emotion. To establish a model of conditioned place aversion (CPA) in morphine-treated rats, we used different visual and tactual cues as conditioned stimuli (CS) within a conditioning apparatus. An injection of naloxone served as the unconditioned stimulus (US). The 6-hydroxydopamine (6-OHDA) lesion technique was used to investigate the effects of the dopaminergic system of the central nucleus of the amygdala (CeA) on naloxone-induced CPA. Rats were rendered physically dependent via administration of increasing doses of morphine delivered via intraperitoneal injection. Doses increased by 20% each day for 14 days, starting from an initial dose of 6 mg/kg. All rats also received a low dose of naloxone (0.1 mg/kg) by injection 4 hours after morphine treatment on days 11 and 13 to induce CPA in a biased two-compartment conditioned place apparatus. Morphine-dependent rats with sham lesions were found to develop significant CPA after naloxone treatment. Bilateral 6-OHDA lesions of the CeA impaired the acquisition of CPA but had no effect on locomotor activity. These results suggest that the dopaminergic system of the CeA plays an important role in the negative affective state of opiate abstinence. |
| 学科主题 | Medical psychology |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the National Basic Research Program (2009CB522002), the Chinese Academy of Sciences (KSCX2-EW-R-12, KSCX2-EW-Q-18), and the National Natural Science Foundation (31070911) |
| 原文出处 | http://www.biomed.cas.cz/physiolres/pdf/61/61_437.pdf |
| 语种 | 英语 |
| WOS记录号 | WOS:000309194600013 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/11865]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Mental Hlth Key Lab, Beijing 100101, Peoples R China 2.Beijing Univ Chem Technol, Sch Humanities & Law, Mental Hlth Educ Res Ctr, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, W.,Li, Y. H.,Tan, B. P.,et al. Inhibition of the Acquisition of Conditioned Place Aversion by Dopaminergic Lesions of the Central Nucleus of the Amygdala in Morphine-Treated Rats[J]. PHYSIOLOGICAL RESEARCH,2012,61(4):437-442. |
| APA | Xu, W..,Li, Y. H..,Tan, B. P..,Luo, X. J..,Xiao, L..,...&Sui, N..(2012).Inhibition of the Acquisition of Conditioned Place Aversion by Dopaminergic Lesions of the Central Nucleus of the Amygdala in Morphine-Treated Rats.PHYSIOLOGICAL RESEARCH,61(4),437-442. |
| MLA | Xu, W.,et al."Inhibition of the Acquisition of Conditioned Place Aversion by Dopaminergic Lesions of the Central Nucleus of the Amygdala in Morphine-Treated Rats".PHYSIOLOGICAL RESEARCH 61.4(2012):437-442. |
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来源：心理研究所
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