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Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats

文献类型：期刊论文

作者Han, Xiao2; Wang, Weiwen3; Shao, Feng2; Li, Nanxin1,2
刊名BRAIN RESEARCH
出版日期2011-04-18
卷号1385页码:175-181
关键词Aggression Dopamine Isolation rearing Nucleus accumbens Prefrontal cortex Serotonin Social interaction
ISSN号0006-8993
产权排序2
通讯作者Li, NX (reprint author), Yale Univ, Sch Med, Div Mol Psychiat, Dept Psychol, 34 Pk St, New Haven, CT 06508 USA.
英文摘要Isolation rearing induces profound behavioral and neurochemical abnormalities in rodents. However, there is some controversy regarding the effect of isolation rearing on social behaviors and monoamine neurotransmission in mesolimbic and mesocortical areas. In the current study, we aimed to address these issues and demonstrated that isolation rearing from weaning to adulthood resulted in increased playful fighting and social contact behaviors. Isolation-reared rats also manifested increased dopamine and serotonin levels in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) as well as an increase in serotonin turnover in the NAc. This study provides additional evidence that social isolation induces alterations in behavior and in the brain. (C) 2011 Elsevier B.V. All rights reserved.
学科主题Physiological psychology/Biological Psychology
收录类别SCI
项目简介This work was supported by the National Natural Science Foundation of China (grant No. 31070910), National Basic Research Program of China (973 Program, 2007CB512306), the Chinese Academy of Sciences (KSCX2-YW-R-131), American Psychological Association, and grants to young scientists from the Institute of Psychology, Chinese Academy of Science (O9KF013001).
原文出处http://ac.els-cdn.com/S0006899311003623/1-s2.0-S0006899311003623-main.pdf?_tid=bc87deac-c219-11e4-9eac-00000aacb362&acdnat=1425437832_c6d5c0a6518363bbac889c172db19230
语种英语
WOS记录号WOS:000289810800019
源URL[http://ir.psych.ac.cn/handle/311026/11879]  
专题心理研究所_中国科学院心理健康重点实验室
作者单位1.Yale Univ, Sch Med, Div Mol Psychiat, Dept Psychol, New Haven, CT 06508 USA
2.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Han, Xiao,Wang, Weiwen,Shao, Feng,et al. Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats[J]. BRAIN RESEARCH,2011,1385:175-181.
APA Han, Xiao,Wang, Weiwen,Shao, Feng,&Li, Nanxin.(2011).Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats.BRAIN RESEARCH,1385,175-181.
MLA Han, Xiao,et al."Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats".BRAIN RESEARCH 1385(2011):175-181.

入库方式： OAI收割

来源：心理研究所

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