Novel vanadyl complexes of alginate saccharides: Synthesis, characterization, and biological activities
文献类型：期刊论文
| 作者 | Liu, Shengyi1,2; Liu, Guangyang1,2; Yi, Yuetao1
|
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2015-05-05 |
| 卷号 | 121页码:86-91 |
| 关键词 | Vanadyl alginate polysaccharides Vanadyl alginate oligosaccharides Antioxidant activity Antiproliferative activity Protein tyrosine phosphatase 1B Cytocompatibility |
| ISSN号 | 0144-8617 |
| 产权排序 | [Liu, Shengyi; Liu, Guangyang; Yi, Yuetao] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Liu, Shengyi; Liu, Guangyang] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 通讯作者 | Yi, YT (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. yiyuetao@gmail.com |
| 英文摘要 | Vanadium compounds present many physiological functions. However, vanadium(IV) and (V) salts are difficult for gastrointestinal absorption and have strong side effects. Therefore organic oxovanadium compounds gain more attention. Vanadyl alginate polysaccharides (VAPS) and vanadyl alginate oligosaccharides (VAOS) were obtained from aqueous solutions of VOSO4 at pH 12. They were characterized by infrared spectroscopy, UV-vis spectroscopy and inductively coupled plasma-mass spectrometry (ICP-MS). The antioxidant activity of oxovanadium(IV) complexes was investigated in hydroxyl and DPPH radical scavenging systems in vitro. The results reveal that activities of VAPS and VAOS in the two systems were stronger than those of alginate polysaccharides (APS) and alginate oligosaccharides (AOS), respectively. In addition, VAPS and VAOS promoted significantly the antiproliferation of ligands of human hepatoma cell line BEL-7402. Oxovanadium(IV) complexes were potent inhibitors of protein tyrosine phosphatase 1B (PTP1B) with IC50 values in the range of 6.4-18.7 mu g/mL, indicated in biochemical assays. In addition, Vanadyl-alginate had no significant side effects on proliferation and viability of HL-7702 hepatic cells. In the future, they can be added to medicines and ease the growing threat that cancer and diabetes mellitus cause to human health. (C) 2014 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| 研究领域[WOS] | Chemistry ; Chemistry; Polymer Science |
| 关键词[WOS] | RADICAL-SCAVENGING ACTIVITY ; ANTIOXIDATIVE ACTIVITIES ; CYTOKINE PRODUCTION ; HYDROGEN-PEROXIDE ; SCHIFF-BASES ; OLIGOSACCHARIDES ; CHITOSAN ; INHIBITION ; DEPOLYMERIZATION ; POLYSACCHARIDES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350182400011 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/8503]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Shengyi,Liu, Guangyang,Yi, Yuetao. Novel vanadyl complexes of alginate saccharides: Synthesis, characterization, and biological activities[J]. CARBOHYDRATE POLYMERS,2015,121:86-91. |
| APA | Liu, Shengyi,Liu, Guangyang,&Yi, Yuetao.(2015).Novel vanadyl complexes of alginate saccharides: Synthesis, characterization, and biological activities.CARBOHYDRATE POLYMERS,121,86-91. |
| MLA | Liu, Shengyi,et al."Novel vanadyl complexes of alginate saccharides: Synthesis, characterization, and biological activities".CARBOHYDRATE POLYMERS 121(2015):86-91. |
入库方式： OAI收割
来源：烟台海岸带研究所
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