Synthesis of amphiphilic aminated inulin via 'click chemistry' and evaluation for its antibacterial activity
文献类型：期刊论文
| 作者 | Dong, Fang1 ; Zhang, Jun2; Yu, Chunwei2; Li, Qing1; Ren, Jianming1; Wang, Gang1; Gu, Guodong3; Guo, Zhanyong1
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2014-09-15 |
| 卷号 | 24期号:18页码:4590-4593 |
| 关键词 | Inulin Click chemistry Selective modification Reactive precursor Antibacterial activity |
| ISSN号 | 0960-894X |
| 产权排序 | [Dong, Fang; Li, Qing; Ren, Jianming; Wang, Gang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Zhang, Jun; Yu, Chunwei] Hainan Med Coll, Sch Trop & Lab Med, Environm Monitoring Lab, Haikou 571199, Peoples R China; [Gu, Guodong] Alliance Pharma Inc, Malvern, PA 19355 USA |
| 通讯作者 | Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. zhanyongguo@hotmail.com |
| 英文摘要 | Inulins are a group of abundant, water-soluble, renewable polysaccharides, which exhibit attractive bioactivities and natural properties. Improvement such as chemical modification of inulin is often performed prior to further utilization. We hereby presented a method to modify inulin at its primary hydroxyls to synthesize amphiphilic aminated inulin via 'click chemistry' to facilitate its chemical manipulation. Additionally, its antibacterial property against Staphylococcus aureus (S. aureus) was also evaluated and the best inhibitory index against S. aureus was 58% at 1 mg/mL. As the amphiphilic aminated inulin is easy to prepare and exhibits improved bioactivity, this material may represent as an attractive new platform for chemical modifications of inulin. (C) 2014 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry, Medicinal ; Chemistry, Organic |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Chemistry |
| 关键词[WOS] | CHITOSAN DERIVATIVES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000341435000046 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/8530]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 烟台海岸带研究所_污染过程与控制实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Hainan Med Coll, Sch Trop & Lab Med, Environm Monitoring Lab, Haikou 571199, Peoples R China 3.Alliance Pharma Inc, Malvern, PA 19355 USA |
| 推荐引用方式 GB/T 7714 | Dong, Fang,Zhang, Jun,Yu, Chunwei,et al. Synthesis of amphiphilic aminated inulin via 'click chemistry' and evaluation for its antibacterial activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(18):4590-4593. |
| APA | Dong, Fang.,Zhang, Jun.,Yu, Chunwei.,Li, Qing.,Ren, Jianming.,...&Guo, Zhanyong.(2014).Synthesis of amphiphilic aminated inulin via 'click chemistry' and evaluation for its antibacterial activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(18),4590-4593. |
| MLA | Dong, Fang,et al."Synthesis of amphiphilic aminated inulin via 'click chemistry' and evaluation for its antibacterial activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.18(2014):4590-4593. |
入库方式： OAI收割
来源：烟台海岸带研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。