Tipping Points in Seaweed Genetic Engineering: Scaling Up Opportunities in the Next Decade
文献类型：期刊论文
| 作者 | Lin, Hanzhi1; Qin, Song2
|
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2014-05-01 |
| 卷号 | 12期号:5页码:3025-3045 |
| 关键词 | seaweed macroalgae genetic engineering GMO gene flow bio-safety marine algae transgenic algae expression system |
| ISSN号 | 1660-3397 |
| 产权排序 | [Lin, Hanzhi] Rutgers State Univ, Inst Marine & Coastal Sci, Environm Biophys & Mol Ecol Program, New Brunswick, NJ 08901 USA; [Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China |
| 通讯作者 | Lin, HZ (reprint author), Rutgers State Univ, Inst Marine & Coastal Sci, Environm Biophys & Mol Ecol Program, 71 Dudley Rd, New Brunswick, NJ 08901 USA. lin@marine.rutgers.edu ; sqin@yic.ac.cn |
| 中文摘要 | Seaweed genetic engineering is a transgenic expression system with unique features compared with those of heterotrophic prokaryotes and higher plants. This study discusses several newly sequenced seaweed nuclear genomes and the necessity that research on vector design should consider endogenous promoters, codon optimization, and gene copy number. Seaweed viruses and artificial transposons can be applied as transformation methods after acquiring a comprehensive understanding of the mechanism of viral infections in seaweeds and transposon patterns in seaweed genomes. After cultivating transgenic algal cells and tissues in a photobioreactor, a biosafety assessment of genetically modified (GM) seaweeds must be conducted before open-sea application. We propose a set of programs for the evaluation of gene flow from GM seaweeds to local/geographical environments. The effective implementation of such programs requires fundamentally systematic and interdisciplinary studies on algal physiology and genetics, marine hydrology, reproductive biology, and ecology. |
| 英文摘要 | Seaweed genetic engineering is a transgenic expression system with unique features compared with those of heterotrophic prokaryotes and higher plants. This study discusses several newly sequenced seaweed nuclear genomes and the necessity that research on vector design should consider endogenous promoters, codon optimization, and gene copy number. Seaweed viruses and artificial transposons can be applied as transformation methods after acquiring a comprehensive understanding of the mechanism of viral infections in seaweeds and transposon patterns in seaweed genomes. After cultivating transgenic algal cells and tissues in a photobioreactor, a biosafety assessment of genetically modified (GM) seaweeds must be conducted before open-sea application. We propose a set of programs for the evaluation of gene flow from GM seaweeds to local/geographical environments. The effective implementation of such programs requires fundamentally systematic and interdisciplinary studies on algal physiology and genetics, marine hydrology, reproductive biology, and ecology. |
| 学科主题 | Chemistry, Medicinal |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | ALGA ECTOCARPUS-SILICULOSUS ; TOLERANT RAPESEED CROPS ; ZINC-FINGER NUCLEASES ; DOUBLE-STRAND BREAKS ; II CORE PROMOTER ; REPORTER GENE ; HUMAN-CELLS ; HOMOLOGOUS RECOMBINATION ; TRANSIENT EXPRESSION ; PROTEIN EXPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337160500037 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/8553]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 作者单位 | 1.Rutgers State Univ, Inst Marine & Coastal Sci, Environm Biophys & Mol Ecol Program, New Brunswick, NJ 08901 USA 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Hanzhi,Qin, Song. Tipping Points in Seaweed Genetic Engineering: Scaling Up Opportunities in the Next Decade[J]. MARINE DRUGS,2014,12(5):3025-3045. |
| APA | Lin, Hanzhi,&Qin, Song.(2014).Tipping Points in Seaweed Genetic Engineering: Scaling Up Opportunities in the Next Decade.MARINE DRUGS,12(5),3025-3045. |
| MLA | Lin, Hanzhi,et al."Tipping Points in Seaweed Genetic Engineering: Scaling Up Opportunities in the Next Decade".MARINE DRUGS 12.5(2014):3025-3045. |
入库方式： OAI收割
来源：烟台海岸带研究所
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