A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo
文献类型：期刊论文
| 作者 | Gao, Min1; Wang, Rui2; Yu, Fabiao2; You, Jinmao1; Chen, Lingxin1,2
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| 刊名 | ANALYST
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| 出版日期 | 2015 |
| 卷号 | 140期号:11页码:3766-3772 |
| 关键词 | REACTIVE OXYGEN SULFANE SULFUR SULFIDE H2S CYSTEINE BIOLOGY PERSULFIDES CHEMISTRY DESIGN THIOLS |
| ISSN号 | 0003-2654 |
| 产权排序 | [Gao, Min; You, Jinmao; Chen, Lingxin] Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China; [Wang, Rui; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China |
| 通讯作者 | Yu, FB (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. fbyu@yic.ac.cn ; lxchen@yic.ac.cn |
| 中文摘要 | Hydrogen polysulfides (H2Sn, n > 1), derived from hydrogen sulfide (H2S), have been considered to be involved in cytoprotective processes and redox signaling. The emerging evidences imply that the actual signaling molecule is H2Sn rather than H2S. In this work, we present a near-infrared fluorescent probe BD-ss for the selective detection of H2Sn biosynthetic pathways in living cells and in vivo. The probe is constructed by equipping a bis-electrophilic H2Sn capture group p-nitrofluorobenzoate to a near-infrared fluorophore azo-BODIPY. BD-ss can provide a remarkable turn-on fluorescence response for assessing endogenous H2Sn formation ways in serum, in living cells and in vivo. |
| 英文摘要 | Hydrogen polysulfides (H2Sn, n > 1), derived from hydrogen sulfide (H2S), have been considered to be involved in cytoprotective processes and redox signaling. The emerging evidences imply that the actual signaling molecule is H2Sn rather than H2S. In this work, we present a near-infrared fluorescent probe BD-ss for the selective detection of H2Sn biosynthetic pathways in living cells and in vivo. The probe is constructed by equipping a bis-electrophilic H2Sn capture group p-nitrofluorobenzoate to a near-infrared fluorophore azo-BODIPY. BD-ss can provide a remarkable turn-on fluorescence response for assessing endogenous H2Sn formation ways in serum, in living cells and in vivo. |
| 学科主题 | Chemistry, Analytical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | REACTIVE OXYGEN ; SULFANE SULFUR ; SULFIDE ; H2S ; CYSTEINE ; BIOLOGY ; PERSULFIDES ; CHEMISTRY ; DESIGN ; THIOLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000354650300011 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/8615]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Min,Wang, Rui,Yu, Fabiao,et al. A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo[J]. ANALYST,2015,140(11):3766-3772. |
| APA | Gao, Min,Wang, Rui,Yu, Fabiao,You, Jinmao,&Chen, Lingxin.(2015).A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo.ANALYST,140(11),3766-3772. |
| MLA | Gao, Min,et al."A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo".ANALYST 140.11(2015):3766-3772. |
入库方式： OAI收割
来源：烟台海岸带研究所
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