Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe
文献类型：期刊论文
| 作者 | Jing, Xiaotong1,2; Yu, Fabiao2; Chen, Lingxin1,2
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| 刊名 | CHEMICAL COMMUNICATIONS
 |
| 出版日期 | 2014 |
| 卷号 | 50期号:91页码:14253-14256 |
| 关键词 | NITRIC-OXIDE LIVING CELLS REDUCTANT-RESISTANT AQUEOUS-SOLUTION REACTIVE OXYGEN NO PRODUCTION CHEMISTRY LIGATION COMPLEX PH |
| ISSN号 | 1359-7345 |
| 产权排序 | [Jing, Xiaotong; Chen, Lingxin] Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China; [Jing, Xiaotong; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China |
| 通讯作者 | Chen, LX (reprint author), Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China. lxchen@yic.ac.cn |
| 中文摘要 | We have presented a near-infrared fluorescent probe Lyso-JN for the detection of nitroxyl (HNO) in cells and in vivo. Lyso-JN is comprised of three moieties: an Aza-BODIPY fluorophore, a HNO-response modulator, diphenylphosphino-benzoyl, and a lysosomal locator, alkylmorpholine. The detection mechanism is based on aza-ylide intramolecular ester aminolysis reaction with HNO. The probe holds the ability to capture lysosomal HNO in RAW 264.7 cells, and it is also successfully employed to visualize HNO in mice. |
| 英文摘要 | We have presented a near-infrared fluorescent probe Lyso-JN for the detection of nitroxyl (HNO) in cells and in vivo. Lyso-JN is comprised of three moieties: an Aza-BODIPY fluorophore, a HNO-response modulator, diphenylphosphino-benzoyl, and a lysosomal locator, alkylmorpholine. The detection mechanism is based on aza-ylide intramolecular ester aminolysis reaction with HNO. The probe holds the ability to capture lysosomal HNO in RAW 264.7 cells, and it is also successfully employed to visualize HNO in mice. |
| 学科主题 | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | NITRIC-OXIDE ; LIVING CELLS ; REDUCTANT-RESISTANT ; AQUEOUS-SOLUTION ; REACTIVE OXYGEN ; NO PRODUCTION ; CHEMISTRY ; LIGATION ; COMPLEX ; PH |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000344226000046 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/8775]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jing, Xiaotong,Yu, Fabiao,Chen, Lingxin. Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe[J]. CHEMICAL COMMUNICATIONS,2014,50(91):14253-14256. |
| APA | Jing, Xiaotong,Yu, Fabiao,&Chen, Lingxin.(2014).Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe.CHEMICAL COMMUNICATIONS,50(91),14253-14256. |
| MLA | Jing, Xiaotong,et al."Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe".CHEMICAL COMMUNICATIONS 50.91(2014):14253-14256. |
入库方式： OAI收割
来源：烟台海岸带研究所
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