Design and Synthesis of Fluorinated Amphiphile as F-19 MRI/Fluorescence Dual-Imaging Agent by Tuning the Self-Assembly
文献类型：期刊论文
| 作者 | Bo, Shaowei1,2,3,5; Song, Cong2,3; Li, Yu2,3; Yu, Weijiang2,3; Chen, Shizhen4; Zhou, Xin4; Yang, Zhigang2,3; Zheng, Xing1,5; Jiang, Zhong-Xing2,3,5 |
| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2015-06-19 |
| 卷号 | 80期号:12页码:6360-6366 |
| 英文摘要 | Both F-19 MRI and optical imaging are powerful noninvasive molecular imaging modalities in biomedical applications. To integrate these two complementary imaging modalities, the design and synthesis of a novel F-19 MRI/fluorescence dual-modal imaging agent is reported herein. Through Sonogashira coupling reaction between the fluorinated phenylacetylene and 1,2,4,5-tetraiodobenzene, a fluorophore with 48 symmetrical fluorines at its periphery was constructed with high efficacy. High aqueous solubility was achieved by PEGylation of the fluorophore with monodisperse PEGs. However, an unexpected self-assembly of the PEGylated amphiphilic fluorophore in water "turned off" the F-19 NMR signal. However, hydrogenation of the triple bonds or introduction of branched monodisperse PEGs was able to efficiently tune the self-assembly, resulting in the "turning on" of the F-19 NMR signal. One of these amphiphiles combines the advantages of label-free fluorescence, high F-19 MRI sensitivity, biocompatibility, and excellent aqueous solubility. The results demonstrate the great potential of such amphiphiles for real-time F-19 MRI and fluorescence dual-modality imaging. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | DETECT PROTEASE ACTIVITY ; MAGNETIC-RESONANCE ; POLY(ETHYLENE GLYCOLS) ; MRI ; NANOPARTICLES ; PROBE ; DENDRIMERS ; SILICA ; NANOPROBES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356845800037 |
| 公开日期 | 2015-08-04 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4853]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Univ South China, Inst Pharm Pharmacol, Hengyang 421001, Peoples R China 2.Wuhan Univ, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Peoples R China 3.Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China 4.Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, Key Lab Magnet Resonance Biol Syst,State Key Lab, Wuhan 430071, Peoples R China 5.Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bo, Shaowei,Song, Cong,Li, Yu,et al. Design and Synthesis of Fluorinated Amphiphile as F-19 MRI/Fluorescence Dual-Imaging Agent by Tuning the Self-Assembly[J]. JOURNAL OF ORGANIC CHEMISTRY,2015,80(12):6360-6366. |
| APA | Bo, Shaowei.,Song, Cong.,Li, Yu.,Yu, Weijiang.,Chen, Shizhen.,...&Jiang, Zhong-Xing.(2015).Design and Synthesis of Fluorinated Amphiphile as F-19 MRI/Fluorescence Dual-Imaging Agent by Tuning the Self-Assembly.JOURNAL OF ORGANIC CHEMISTRY,80(12),6360-6366. |
| MLA | Bo, Shaowei,et al."Design and Synthesis of Fluorinated Amphiphile as F-19 MRI/Fluorescence Dual-Imaging Agent by Tuning the Self-Assembly".JOURNAL OF ORGANIC CHEMISTRY 80.12(2015):6360-6366. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。