Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1
文献类型：期刊论文
| 作者 | Chen, Chunmei; Zhu, Hucheng; Wang, Jianping; Yang, Jing ; Li, Xiao-Nian; Wang, Jing; Chen, Keliang; Wang, Yanyan; Luo, Zengwei; Yao, Guangmin
|
| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2015-05-01 |
| 期号 | 14页码:3086-3094 |
| 关键词 | Natural products Drug discovery Antiviral agents Polycycles Structure elucidation |
| 通讯作者 | Xue,YB (reprint author),Huazhong Univ Sci & Technol,Sch Pharm,Tongji Med Coll,Hubei Key Lab Nat Med Chem & Resource Evaluat,Wuhan 430030,Peoples R China. ; yongboxue@mail.hust.edu.cn ; zhangyh@mails.tjmu.edu.cn |
| 英文摘要 | Eight rare pyrrole-based cytochalasans, termed armochaetoglobins K-R (1-8), along with three known analogues (9-11), were isolated from the solid culture broth of Chaetomium globosum TW1-1, a symbiotic fungus derived from the medicinal terrestrial arthropod Armadillidium vulgare. Their structures were elucidated using a combination of spectroscopic analysis, a single-crystal X-ray diffraction experiment, and an electronic circular dichroism (ECD) calculation. Compounds 4-8 represent the first examples of chaetoglobosin-type cytochalasans with an sp(3) methine carbon at C-18. All of the isolates were evaluated for their anti-HIV activities in vitro, and compounds 2-4, 7, 8, and 10 showed significant anti-HIV activities, with EC50 values ranging from 0.11 to 0.55 mu M, and selectivity index (SI) values ranging from 12.33 to 75.42. A plausible biosynthetic pathway was proposed to explain the origin of the pyrrole ring. |
| 学科主题 | Chemistry, Organic |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | CYTOTOXIC CYTOCHALASANS ; ENDOPHYTIC FUNGUS ; CHAETOGLOBOSIN ; BIOSYNTHESIS ; METABOLITES ; SKELETON ; AGENT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000354212000015 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/21350]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen, Chunmei,Zhu, Hucheng,Wang, Jianping,et al. Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2015(14):3086-3094. |
| APA | Chen, Chunmei.,Zhu, Hucheng.,Wang, Jianping.,Yang, Jing.,Li, Xiao-Nian.,...&Zhang, Yonghui.(2015).Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(14),3086-3094. |
| MLA | Chen, Chunmei,et al."Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .14(2015):3086-3094. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。