Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors
文献类型：期刊论文
| 作者 | Chen, Duozhi; Cai, Jieyun; Yin, Junlin; Jiang, Jiandong; Jing, Chenxu; Zhu, Yanping; Cheng, Junjun; Di, Yingtong ; Zhang, Yu; Cao, Mingming
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| 刊名 | FUTURE MEDICINAL CHEMISTRY
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| 出版日期 | 2015 |
| 卷号 | 7期号:5页码:561-570 |
| 通讯作者 | Hao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China. ; haoxj@mail.kib.ac.cn |
| 英文摘要 | Background: A new series of potential phenanthridine hepatitis C virus (HCV) inhibitors which work by suppressing Hsc70 expression in the host cell was designed and synthesized from lycorine. Results: Thirty-one new potential phenanthridine HCV inhibitors were synthesized and five of these compounds exhibited good anti-HCV activity and these inhibitors probably inhibit HCV by downregulating the host Hsc70 expression. Structure-activity analysis of these compounds revealed that the double bond between C-11 and C-12 and the substituents at C-8 and C-9 are important for their activity against HCV. Conclusion: Suppression of Hsc70 expression in the host cell to limit HCV replication is a potential anti-HCV strategy. Phenanthridines are probably the HCV inhibitors with this mode of action. |
| 学科主题 | Chemistry, Medicinal |
| 类目[WOS] | Chemistry, Medicinal |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | RESISTANCE ; REPLICATION ; AMARYLLIDACEAE ; INFECTION ; PROGRESS ; RNA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000354104900004 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/21351]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen, Duozhi,Cai, Jieyun,Yin, Junlin,et al. Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors[J]. FUTURE MEDICINAL CHEMISTRY,2015,7(5):561-570. |
| APA | Chen, Duozhi.,Cai, Jieyun.,Yin, Junlin.,Jiang, Jiandong.,Jing, Chenxu.,...&Hao, Xiaojiang.(2015).Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors.FUTURE MEDICINAL CHEMISTRY,7(5),561-570. |
| MLA | Chen, Duozhi,et al."Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors".FUTURE MEDICINAL CHEMISTRY 7.5(2015):561-570. |
入库方式： OAI收割
来源：昆明植物研究所
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