A cinchona alkaloid catalyzed enantioselective sulfa-Michael/aldol cascade reaction of isoindigos: construction of chiral bispirooxindole tetrahydrothiophenes with vicinal quaternary spirocenters
文献类型：期刊论文
| 作者 | Gui, Yong-Yuan1,2; Yang, Jian1,2; Qi, Liang-Wen1,2; Wang, Xiao1,2; Tian, Fang1; Li, Xiao-Nian3; Peng, Lin1; Wang, Li-Xin1 |
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 13期号:22页码:6371-6379 |
| 通讯作者 | Peng,L (reprint author),Chinese Acad Sci,Chengdu Inst Organ Chem,Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro,Chengdu 610041,Peoples R China. |
| 英文摘要 | A cinchona alkaloid catalyzed diastereoselective and enantioselective sulfa-Michael/aldol cascade reaction between 1,4-dithiane-2,5-diol and isoindigos has been successfully developed to afford the highly congested bispirooxindole tetrahydrothiophenes with vicinal quaternary spirocenters in high yields (up to 91%), excellent diastereoselectivities (up to >20 : 1 dr), and good enantioselectivities (up to 98% ee). Some synthetic transformations of the reaction products were also studied. |
| 学科主题 | Chemistry, Organic |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | TRISUBSTITUTED TETRAHYDROTHIOPHENES ; SPIROCYCLOPENTANE BIOXINDOLES ; ISOTHIOCYANATO OXINDOLES ; CONTIGUOUS STEREOCENTERS ; SPIROCYCLIC OXINDOLES ; ASYMMETRIC-SYNTHESIS ; 3+2 CYCLOADDITION ; HIGHLY EFFICIENT ; DERIVATIVES ; SPIROOXINDOLES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000355489600028 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/21353]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gui, Yong-Yuan,Yang, Jian,Qi, Liang-Wen,et al. A cinchona alkaloid catalyzed enantioselective sulfa-Michael/aldol cascade reaction of isoindigos: construction of chiral bispirooxindole tetrahydrothiophenes with vicinal quaternary spirocenters[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2015,13(22):6371-6379. |
| APA | Gui, Yong-Yuan.,Yang, Jian.,Qi, Liang-Wen.,Wang, Xiao.,Tian, Fang.,...&Wang, Li-Xin.(2015).A cinchona alkaloid catalyzed enantioselective sulfa-Michael/aldol cascade reaction of isoindigos: construction of chiral bispirooxindole tetrahydrothiophenes with vicinal quaternary spirocenters.ORGANIC & BIOMOLECULAR CHEMISTRY,13(22),6371-6379. |
| MLA | Gui, Yong-Yuan,et al."A cinchona alkaloid catalyzed enantioselective sulfa-Michael/aldol cascade reaction of isoindigos: construction of chiral bispirooxindole tetrahydrothiophenes with vicinal quaternary spirocenters".ORGANIC & BIOMOLECULAR CHEMISTRY 13.22(2015):6371-6379. |
入库方式： OAI收割
来源：昆明植物研究所
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