Vibsanin B Preferentially Targets HSP90b, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis
文献类型：期刊论文
| 作者 | Ye, Bai-Xin; Deng, Xu ; Shao, Li-Dong; Lu, Ying; Xiao, Run; Liu, Yi-Jie; Jin, Yi; Xie, Yin-Yin; Zhao, Yan; Luo, Liu-Fei
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| 刊名 | JOURNAL OF IMMUNOLOGY
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| 出版日期 | 2015-05-01 |
| 卷号 | 194期号:9页码:4489-4497 |
| 通讯作者 | Chen,Z (reprint author),Shanghai Jiao Tong Univ,RuiJin Hosp,Sch Med,197 Rui Jin Rd 2,Shanghai 200025,Peoples R China. ; qinshizhao@mail.kib.ac.cn ; sjchen@stn.sh.cn ; zchen@stn.sh.cn |
| 英文摘要 | Interstitial leukocyte migration plays a critical role in inflammation and offers a therapeutic target for treating inflammation-associated diseases such as multiple sclerosis. Identifying small molecules to inhibit undesired leukocyte migration provides promise for the treatment of these disorders. In this study, we identified vibsanin B, a novel macrocyclic diterpenoid isolated from Viburnum odoratissimum Ker-Gawl, that inhibited zebrafish interstitial leukocyte migration using a transgenic zebrafish line (TG:zlyz-enhanced GFP). We found that vibsanin B preferentially binds to heat shock protein (HSP)90b. At the molecular level, inactivation of HSP90 can mimic vibsanin B's effect of inhibiting interstitial leukocyte migration. Furthermore, we demonstrated that vibsanin B ameliorates experimental autoimmune encephalomyelitis in mice with pathological manifestation of decreased leukocyte infiltration into their CNS. In summary, vibsanin B is a novel lead compound that preferentially targets HSP90 beta and inhibits interstitial leukocyte migration, offering a promising drug lead for treating inflammation-associated diseases. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 研究领域[WOS] | Immunology |
| 关键词[WOS] | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS ; BIOLOGICAL-ACTIVITIES ; MULTIPLE-SCLEROSIS ; NATURAL-PRODUCTS ; DRUG DISCOVERY ; CELL-MIGRATION ; ZEBRAFISH ; INFLAMMATION ; MOTILITY ; CANCER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000353727400047 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/21355]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Ye, Bai-Xin,Deng, Xu,Shao, Li-Dong,et al. Vibsanin B Preferentially Targets HSP90b, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis[J]. JOURNAL OF IMMUNOLOGY,2015,194(9):4489-4497. |
| APA | Ye, Bai-Xin.,Deng, Xu.,Shao, Li-Dong.,Lu, Ying.,Xiao, Run.,...&Chen, Zhu.(2015).Vibsanin B Preferentially Targets HSP90b, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis.JOURNAL OF IMMUNOLOGY,194(9),4489-4497. |
| MLA | Ye, Bai-Xin,et al."Vibsanin B Preferentially Targets HSP90b, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis".JOURNAL OF IMMUNOLOGY 194.9(2015):4489-4497. |
入库方式： OAI收割
来源：昆明植物研究所
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