Xanthine oxidase inhibitors isolated from Piper nudibaccatum
文献类型：期刊论文
| 作者 | Liu, Hong-Xin1,2,3,4; He, Meng-Ting5; Tan, Hai-Bo3; Gu, Wei1,2 ; Yang, Shi-Xian1,2; Wang, Yue-Hu1,2; Li, Ling5; Long, Chun-Lin1,2,6
|
| 刊名 | PHYTOCHEMISTRY LETTERS
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 12页码:133-137 |
| 关键词 | Piper nudibaccatum Hydroxychavicol Nudibaccatumin A Nudibaccatumin B Xanthine oxidase |
| 通讯作者 | Long,CL (reprint author),Minzu Univ China,Coll Life & Environm Sci,Beijing 100081,Peoples R China. ; kmli62@163.com ; long@mail.kib.ac.cn |
| 英文摘要 | Two new hydroxychavicol analogs nudibaccatumin A (1) and B (2), together with twenty known compounds were isolated from the methanol extract of Piper nudibaccatum. Their structures were elucidated by extensive spectroscopic analyses (1D and 2D NMR, HRESIMS, UV, IR and polarimetry). Hydroxychavicol is a known inhibitor of xanthine oxidase (XO). In the present study, hydroxychavicol and 5 natural analogs (1-5) were evaluated for their XO inhibitory activity. Neotaiwanensol B (3) (IC50 = 0.28 mu M) showed a greater inhibitory effect than hydroxychavicol and allopurinol (the positive control). Two new compounds 1 and 2 showed a moderate inhibition activity with an IC50 value of 62.94 mu M and 70.67 mu M, respectively. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Plant Sciences |
| 类目[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
| 关键词[WOS] | LONGUM L ; FLAVONOIDS ; AMIDE ; CONSTITUENTS ; DERIVATIVES ; MECHANISM ; FRUITS ; ACID ; GOUT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356336400025 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/21321]  |
| 专题 | 昆明植物研究所_资源植物与生物技术所级重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Peoples R China 3.Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 5.Kunming Med Univ, Biomed Engn Res Ctr, Kunming 650500, Peoples R China 6.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Hong-Xin,He, Meng-Ting,Tan, Hai-Bo,et al. Xanthine oxidase inhibitors isolated from Piper nudibaccatum[J]. PHYTOCHEMISTRY LETTERS,2015,12:133-137. |
| APA | Liu, Hong-Xin.,He, Meng-Ting.,Tan, Hai-Bo.,Gu, Wei.,Yang, Shi-Xian.,...&Long, Chun-Lin.(2015).Xanthine oxidase inhibitors isolated from Piper nudibaccatum.PHYTOCHEMISTRY LETTERS,12,133-137. |
| MLA | Liu, Hong-Xin,et al."Xanthine oxidase inhibitors isolated from Piper nudibaccatum".PHYTOCHEMISTRY LETTERS 12(2015):133-137. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。