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Impact of silver nanoparticles on human cells: Effect of particle size
文献类型：期刊论文
| 作者 | Liu, Wei ; Wu, Yuan ; Wang, Chang ; Li, Hong C. ; Wang, Thanh ; Liao, Chun Y. ; Cui, Lin ; Zhou, Qun F. ; Yan, Bing ; Jiang, Gui B. |
| 刊名 | NANOTOXICOLOGY
 |
| 出版日期 | 2010-09 |
| 卷号 | 4期号:3页码:319-330 |
| 关键词 | Silver nanoparticles cytotoxicity size-dependent |
| 中文摘要 | This work investigated the cytotoxicities of three silver nanoparticles (SNPs) SNP-5, SNP-20 and SNP-50 with different sizes (similar to 5 nm, similar to 20 nm and similar to 50 nm) using four human cell models (A549, SGC-7901, HepG2 and MCF-7). Endpoints included cell morphology, cell viability, cellular membrane integrity, oxidative stress and cell cycle progression. Observable deleterious effects on the cell morphologies and membrane integrity were induced by SNP-5 and SNP-20. SNPs elevated the ROS levels in cells and arrested the cells at S phase. Apoptosis occurred for 4-9% of the exposed cells. All these cellular responses as well as EC50 values were found to be size-dependent for the tested SNPs. Ultrastructural observations confirmed the presence of SNPs inside cells. Elemental analysis of silver in cells by ICP-MS showed that smaller nanoparticles enter cells more easily than larger ones, which may be the cause of higher toxic effects. The findings may assist in the design of SNP applications and provide insights into their toxicity. |
| WOS记录号 | WOS:000283555100006 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21088]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu, Wei,Wu, Yuan,Wang, Chang,et al. Impact of silver nanoparticles on human cells: Effect of particle size[J]. NANOTOXICOLOGY,2010,4(3):319-330. |
| APA | Liu, Wei.,Wu, Yuan.,Wang, Chang.,Li, Hong C..,Wang, Thanh.,...&Jiang, Gui B..(2010).Impact of silver nanoparticles on human cells: Effect of particle size.NANOTOXICOLOGY,4(3),319-330. |
| MLA | Liu, Wei,et al."Impact of silver nanoparticles on human cells: Effect of particle size".NANOTOXICOLOGY 4.3(2010):319-330. |
入库方式： OAI收割
来源：生态环境研究中心
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