Inflammatory response and insulin signaling alteration induced by PCB77
文献类型：期刊论文
| 作者 | Wang, Jing ; Lv, Xiaowen ; Du, Yuguo |
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA
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| 出版日期 | 2010 |
| 卷号 | 22期号:7页码:1086-1090 |
| 关键词 | PCB77 pro-inflammatory cytokines IL-6 TNF alpha NF kappa B Akt |
| 中文摘要 | A specific mechanism whereby inflammation may contribute to cardiovascular diseases (CVD), insulin resistance (IR) and type II diabetes is the induction of endothelial dysfunction placing the vascular endothelium in a key unifying position for the shared pathogenesis of these diseases. However, the mechanisms by which PCBs induce endothelial cell dysfunction are not clearly understood. In the present study, we used human umbilical vascular endothelial cells (HUVEC) as model, and inflammatory response and insulin signaling alteration induced by PCBs were examined. Results showed that PCB77 induced the expression of proinflammatory cytokines including IL-6 and TNF alpha and induced U937 adhesion to HUVEC cells consistent with increased NF kappa B transcription activity. On the other hand, PCB77 blocked insulin-activated Akt signaling pathway, which was restored by pretreatment with TNF alpha neutralization antibody. In conclusion, PCB77 showed the potential to induce the expression of proinflammatory cytokines including IL-6, which has been shown to be powerful independent risk predictor of CVD. And PCB77 was observed to alter insulin-activated Akt signaling by TNF alpha secretion for the first time. |
| WOS记录号 | WOS:000280163800018 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21091]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wang, Jing,Lv, Xiaowen,Du, Yuguo. Inflammatory response and insulin signaling alteration induced by PCB77[J]. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,2010,22(7):1086-1090. |
| APA | Wang, Jing,Lv, Xiaowen,&Du, Yuguo.(2010).Inflammatory response and insulin signaling alteration induced by PCB77.JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,22(7),1086-1090. |
| MLA | Wang, Jing,et al."Inflammatory response and insulin signaling alteration induced by PCB77".JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA 22.7(2010):1086-1090. |
入库方式： OAI收割
来源：生态环境研究中心
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