Thermo-sensitive amphiphilic poly(N-vinylcaprolactam) copolymers: synthesis and solution properties
文献类型：期刊论文
| 作者 | Zhang, Lifen; Liang, Yong; Meng, Lingzhi |
| 刊名 | POLYMERS FOR ADVANCED TECHNOLOGIES
 |
| 出版日期 | 2010-10 |
| 卷号 | 21期号:10页码:720-725 |
| 关键词 | amphiphiles self-assembly solution properties thermo-sensitive N-vinylcaprolactam |
| 中文摘要 | Thermo-sensitive amphiphilic copolymers, PVCL-PTrpAMT and PVCL-PVP-PTrpAMT of hydrophilic N-vinylcaprolactam (VCL), N-vinylpyrrolidone (NVP), and hydrophobic N-t-Boc-tryptophanamido-N'-methacryl thioureas (TrpAMT) monomers, were synthesized and characterized by (1)H NMR, UV-spectroscopy, and GPC-MALLS. The cloud point (CP) measurement showed that hydrophobic PTrpAMT and hydrophilic PVP segments significantly altered the phase transition temperature of PVCL with comparable molecular weight in aqueous solution. The CP of PVP-PTrpAMT solution was 38.0 degrees C, lower by 5.0 degrees C than that of unmodified PVCL. In the presence of phosphate buffer saline (PBS), the CP value of the PVCL polymer decreased by similar to 2.0 degrees C in comparison to that of the aqueous solution. Fluorescent spectroscopy and TEM studies revealed that PVCL-PTrpAMT and PVCL-PVP-PTrpAMT self-assembled into the spherical micelles, 30-70 nm in diameter, at concentrations over their CMCs in an aqueous solution. Cytotoxicity tests demonstrated that the PVCL copolymers were not harmful to cell viability, which may favor the use of the copolymers as potential thermo-sensitive polymers in pharmaceutical applications. Copyright (c) 2009 John Wiley & Sons, Ltd. |
| WOS记录号 | WOS:000282400000006 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21159]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, Lifen,Liang, Yong,Meng, Lingzhi. Thermo-sensitive amphiphilic poly(N-vinylcaprolactam) copolymers: synthesis and solution properties[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2010,21(10):720-725. |
| APA | Zhang, Lifen,Liang, Yong,&Meng, Lingzhi.(2010).Thermo-sensitive amphiphilic poly(N-vinylcaprolactam) copolymers: synthesis and solution properties.POLYMERS FOR ADVANCED TECHNOLOGIES,21(10),720-725. |
| MLA | Zhang, Lifen,et al."Thermo-sensitive amphiphilic poly(N-vinylcaprolactam) copolymers: synthesis and solution properties".POLYMERS FOR ADVANCED TECHNOLOGIES 21.10(2010):720-725. |
入库方式： OAI收割
来源：生态环境研究中心
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