Thyroid disruption by technical decabromodiphenyl ether (DE-83R) at low concentrations in Xenopus laevis
文献类型：期刊论文
| 作者 | Qin, Xiaofei ; Xia, Xijuan ; Yang, Zhongzhi ; Yan, Shishuai ; Zhao, Yaxian ; Wei, Rongguo ; Li, Yan ; Tian, Mi ; Zhao, Xingru ; Qin, Zhanfen ; Xu, Xiaobai |
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA
 |
| 出版日期 | 2010 |
| 卷号 | 22期号:5页码:744-751 |
| 关键词 | decabromodiphenyl ether Xenopus laevis thyroid disruption metamorphosis thyroid hormone receptor |
| 中文摘要 | Decabromodiphenyl ether (decaBDE), as a flame retardant, is widely produced and used. To study the thyroid disruption by technical decaBDE at low concentrations, Xenopus laevis tadpoles were exposed to technical decaBDE mixture DE-83R (1-1000 ng/L) in water from stage 46/47 (free swimming larvae, system of Nieuwkoop and Faber) to stage 62. DE-83R at concentration of 1000 ng/L significantly delayed the time to metamorphosis (presented by forelimb emergence, FLE). Histological examination showed that DE-83R at all tested concentrations caused histological alterations multilayer follicular epithelial cell and markedly increased follicle size accompanied by partial colloid depletion and increase in the peripheral colloid vacuolation, in thyroid glands. All tested concentrations of DE-83R also induced a down-regulation of thyroid receptor mRNA expression. These results demonstrated that technical decaBDE disrupted the thyroid system in X. laevis tadpoles. Analysis of polybrominated diphenyl ethers (PBDEs) (sum of 39 congeners) in X. laevis indicated that mean concentrations of total PBDEs in X. laevis exposed to 1, 10, 100, 1000 ng/L were 11.0, 128.1, 412.1, 1400.2 ng/g wet weight, respectively. Considering that PBDEs burden of X. laevis tadpoles was close to PBDEs levels in amphibians as reported in previous studies, our study has raised new concerns for thyroid disruption in amphibians of technical decaBDE at environmentally relevant concentrations. |
| WOS记录号 | WOS:000277782600016 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21160]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Qin, Xiaofei,Xia, Xijuan,Yang, Zhongzhi,et al. Thyroid disruption by technical decabromodiphenyl ether (DE-83R) at low concentrations in Xenopus laevis[J]. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,2010,22(5):744-751. |
| APA | Qin, Xiaofei.,Xia, Xijuan.,Yang, Zhongzhi.,Yan, Shishuai.,Zhao, Yaxian.,...&Xu, Xiaobai.(2010).Thyroid disruption by technical decabromodiphenyl ether (DE-83R) at low concentrations in Xenopus laevis.JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,22(5),744-751. |
| MLA | Qin, Xiaofei,et al."Thyroid disruption by technical decabromodiphenyl ether (DE-83R) at low concentrations in Xenopus laevis".JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA 22.5(2010):744-751. |
入库方式： OAI收割
来源：生态环境研究中心
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