Alterations in mRNA expression of steroid receptors and heat shock proteins in the liver of rare minnow (Grobiocypris rarus) exposed to atrazine and p,p '-DDE
文献类型：期刊论文
| 作者 | Yang, Lihua; Zha, Jinmiao; Zhang, Xiaoyan; Li, Wei; Li, Zhaoli; Wang, Zijian |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2010-07-15 |
| 卷号 | 98期号:4页码:381-387 |
| 关键词 | Atrazine p Rare minnow (Gobiocypris rants) Heat shock proteins Steroid receptors p '-DDE |
| 中文摘要 | The chaperon role of heat shock proteins (HSPs) throughout the life cycle of steroid receptors have been demonstrated in vitro. However, the actions of HSPs in steroid pathways in animals especially in fish were unclear. In this study, sexually mature rare minnows (Gobiocypris rarus) were exposed to typical endocrine disruptors (atrazine and p,p'-DDE). Hypertrophy of hepatocytes at the 333 mu g/l atrazine treatment and atrophy of hepatocytes in all p,p'-DDE treatments were observed. The expression of liver hsp70 and hsp90 in atrazine treatments were significantly up-regulated. Moreover, remarkable increases in the expression of androgen receptor (or) and estrogen receptor (er)were observed, while alterations of the glucoticorcoid receptor (gr) expression was not significant in atrazine exposed fish. The expression of ar, er, gr, hsp70 and hsp90 were significantly suppressed following p,p'-DDE exposure. These results demonstrate that the expression of hsp70 and hsp90 is altered along with changes of steroid receptors in vivo. Therefore, the results are consistent with the possibility that in fish heat shock proteins (HSPs) play chaperon roles for the steroid receptors in vivo, which also concurs with previous in vitro mammalian studies. (C) 2010 Elsevier B.V. All rights reserved. |
| WOS记录号 | WOS:000278982800009 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21199]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Yang, Lihua,Zha, Jinmiao,Zhang, Xiaoyan,et al. Alterations in mRNA expression of steroid receptors and heat shock proteins in the liver of rare minnow (Grobiocypris rarus) exposed to atrazine and p,p '-DDE[J]. AQUATIC TOXICOLOGY,2010,98(4):381-387. |
| APA | Yang, Lihua,Zha, Jinmiao,Zhang, Xiaoyan,Li, Wei,Li, Zhaoli,&Wang, Zijian.(2010).Alterations in mRNA expression of steroid receptors and heat shock proteins in the liver of rare minnow (Grobiocypris rarus) exposed to atrazine and p,p '-DDE.AQUATIC TOXICOLOGY,98(4),381-387. |
| MLA | Yang, Lihua,et al."Alterations in mRNA expression of steroid receptors and heat shock proteins in the liver of rare minnow (Grobiocypris rarus) exposed to atrazine and p,p '-DDE".AQUATIC TOXICOLOGY 98.4(2010):381-387. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。