Atrazine affects kidney and adrenal hormones (AHs) related genes expressions of rare minnow (Gobiocypris rarus)
文献类型：期刊论文
| 作者 | Yang, Lihua ; Zha, Jinmiao ; Li, Wei ; Li, Zhaoli ; Wang, Zijian |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2010-05-05 |
| 卷号 | 97期号:3页码:204-211 |
| 关键词 | Atrazine Histopathology Adrenal hormones disruption Rare minnow (Gobiocypris rams) |
| 中文摘要 | Atrazine, one of the most widely used herbicides, has been proved to interfere with sexual hormones. However few studies have considered the effects of atrazine on adrenal hormones (AH). In this study, rare minnow (Gobiocypris torus) was exposed to 0, 3, 10, 33, 100 and 333 mu g/l atrazine for 28 days. The histopathology of kidney and gill was examined and the expressions of AHs-related genes including Na(+),K(+)-ATPase, glucocorticoid receptor (gr), heat shock protein 70 (hsp70), and heat shock protein 90 (hsp90) in kidney and gill were quantitatively determined. Histopathological observation revealed obvious lesions in gill including hyperplasia, necrosis in epithelium region, aneurysm and lamellar fusion at concentrations as low as 10 mu g/l. The observed lesions in kidney included extensive expansion in the lumen, degenerative and necrotic changes of the tubular epithelia, shrinkage of the glomerulus as well as increase of the Bowman's space at concentrations as low as 10 mu g/l. The expressions of Na(+),K(+)-ATPase, gr, hsp70 and hsp90 in the kidney of females were significantly decreased at all concentrations. For males. the expressions of hsp90 in the kidney of all treated groups were significantly down-regulated, while gr at all concentrations and hsp70 at 10, 33, 100 mu g/l were significantly up-regulated. However in the gill, the expressions of these genes were not significantly different from the control. These results indicated that exposure to atrazine caused impairments of kidney and gill of fish at environmental related concentrations. Histopathological lesions could partly attribute to the changes of the expressions of AHs-related genes in kidney. We concluded also that atrazine is a potential AHs-disruptor and AHs-related genes in kidney of fish could be used as sensitive molecular biomarkers. (C) 2009 Elsevier B.V. All rights reserved. |
| WOS记录号 | WOS:000277782100005 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21209]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Yang, Lihua,Zha, Jinmiao,Li, Wei,et al. Atrazine affects kidney and adrenal hormones (AHs) related genes expressions of rare minnow (Gobiocypris rarus)[J]. AQUATIC TOXICOLOGY,2010,97(3):204-211. |
| APA | Yang, Lihua,Zha, Jinmiao,Li, Wei,Li, Zhaoli,&Wang, Zijian.(2010).Atrazine affects kidney and adrenal hormones (AHs) related genes expressions of rare minnow (Gobiocypris rarus).AQUATIC TOXICOLOGY,97(3),204-211. |
| MLA | Yang, Lihua,et al."Atrazine affects kidney and adrenal hormones (AHs) related genes expressions of rare minnow (Gobiocypris rarus)".AQUATIC TOXICOLOGY 97.3(2010):204-211. |
入库方式： OAI收割
来源：生态环境研究中心
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