In vitro profiling of endocrine disrupting effects of phenols
文献类型：期刊论文
| 作者 | Li, Jian ; Ma, Mei ; Wang, Zijian |
| 刊名 | TOXICOLOGY IN VITRO
 |
| 出版日期 | 2010-02 |
| 卷号 | 24期号:1页码:201-207 |
| 关键词 | Phenols Androgen receptor Progesterone receptor Estrogen-related receptor Yeast two-hybrid assay Estrogen receptor |
| 中文摘要 | Some phenols have been suspected to modulate the endocrine systems of wildlife and humans, but less is known about their interactions with different types of nuclear receptors. In this study, the ability of 2-tert-butylphenol, 2-isopropylphenol, 4-tert-octylphenol (4-t-OP), 2,4-dichlorophenol (2,4-DCP). 3,4-dichlorophenol (3,4-DCP), pentachloro phenol (PCP), bisphenols A (BPA), tetrabromobisphenol A (TBBPA), tetrachlorobisphenol A (TCBPA) and 4-phenylphenol to activate estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR) and estrogen-related receptor (ERR) were determined using a set of recombined yeast strains. It was found that 4-t-OP, 3,4-DCP, PCP, BPA, TBBPA, TCBPA and 4-phenylphenol were ER alpha agonists, while 4-t-OP, PCP and 4-phenylphenol showed ER alpha antagonistic activities. 2-tert-Butylphenol, 4-t-OP, 2-isopropyl phenol, 2,4-DCP, 3,4-DCP, BPA, TCBPA and 4-phenylphenol were antagonists for AR, whereas none of the compounds studied were found to be an AR agonist. TCBPA, TBBPA and PCP were PR antagonists, and 2-tert-butylphenol, 3,4-DCP, 4-t-OP, 4-phenylphenol and 2-isopropylphenol were weak inhibitors on expression under control of the PR. None of the phenols were PR agonists. 2-tert-Butylphenol, 4-t-OP and PCP were ERR gamma inverse agonists, while 2,4-DCP, 3,4-DCP, PCP, BPA, TBBPA and TCBPA exhibited the ability to reverse the ERR inhibition induced by 4-hydroxytamoxifen. Based on the functional agonistic or antagonistic receptor-mediated effects, we further discussed the possible action mechanisms of these phenols as endocrine disrupting chemicals. (C) 2009 Elsevier Ltd. All rights reserved. |
| WOS记录号 | WOS:000273930000026 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21245]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Jian,Ma, Mei,Wang, Zijian. In vitro profiling of endocrine disrupting effects of phenols[J]. TOXICOLOGY IN VITRO,2010,24(1):201-207. |
| APA | Li, Jian,Ma, Mei,&Wang, Zijian.(2010).In vitro profiling of endocrine disrupting effects of phenols.TOXICOLOGY IN VITRO,24(1),201-207. |
| MLA | Li, Jian,et al."In vitro profiling of endocrine disrupting effects of phenols".TOXICOLOGY IN VITRO 24.1(2010):201-207. |
入库方式： OAI收割
来源：生态环境研究中心
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