Toxicokinetics and the related metabolites in rainbow trout (Oncorhynchus mykiss) after exposure to decabromodiphenyl ether
文献类型：期刊论文
| 作者 | Feng ChengLian; Xu YiPing; Zha JinMiao; Luo Qian; Shan XiaoQuan; Wang ZiJian |
| 刊名 | SCIENCE CHINA-CHEMISTRY
 |
| 出版日期 | 2010-11 |
| 卷号 | 53期号:11页码:2379-2386 |
| 关键词 | decabromodiphenyl ether (BDE209) polybrominated diphenyl ethers (PBDEs) methoxylated brominated diphenyl ethers (MeO-BDEs) toxicokinetics rainbow trout |
| 中文摘要 | Decabromodiphenyl ether (BDE209) is poorly absorbed by mammals, and little information is available on the toxicokinetics of BDE209 and its metabolites in fish. In the present study, rainbow trout (Oncorhynchus mykiss) were administered to 100 ng/g and 500 ng/g body wet weight of BDE209 via a single intraperitoneal injection and parent BDE209 and its metabolites were sequentially monitored for 28 days. The results showed that toxicokinetic profiles of BDE209 could be described by the one-compartment model. In the higher dose group (500 ng/g wet weight), the calculated half-life (t(1/2)) and elimination rate (k(e)) were 17.7 d and 0.039/d in the liver, and 100.3 d and 0.007/d in the muscle, respectively. Three major methoxylated brominated diphenyl ethers (MeO-BDEs) were detected with 2,2',4,4'-tetrabromo-5-methoxydiphenyl ether (5-MeO-BDE47) being detected in all tissue samples. There was no significant temporal change of 5-MeO-BDE47 concentration in the muscle, whereas an exponential increase was observed in the liver. Therefore, the metabolism rate of BDE209 depended on the administered dose. BDE209 was hardly accumulated in the muscle of rainbow trout, while the liver was a primary metabolic organ. MeO-BDEs were formed via metabolism of BDE209, which probably played a significant role in fish toxicology as a potential indicator. |
| WOS记录号 | WOS:000284078200025 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21287]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Feng ChengLian,Xu YiPing,Zha JinMiao,et al. Toxicokinetics and the related metabolites in rainbow trout (Oncorhynchus mykiss) after exposure to decabromodiphenyl ether[J]. SCIENCE CHINA-CHEMISTRY,2010,53(11):2379-2386. |
| APA | Feng ChengLian,Xu YiPing,Zha JinMiao,Luo Qian,Shan XiaoQuan,&Wang ZiJian.(2010).Toxicokinetics and the related metabolites in rainbow trout (Oncorhynchus mykiss) after exposure to decabromodiphenyl ether.SCIENCE CHINA-CHEMISTRY,53(11),2379-2386. |
| MLA | Feng ChengLian,et al."Toxicokinetics and the related metabolites in rainbow trout (Oncorhynchus mykiss) after exposure to decabromodiphenyl ether".SCIENCE CHINA-CHEMISTRY 53.11(2010):2379-2386. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。