In vivo assessment of the oxidative and apoptotic potential of perfluorooctanoic acid
文献类型：期刊论文
| 作者 | Yang, Shaoli(1); Su, Zhen(1) |
| 刊名 | BioTechnology: An Indian Journal
 |
| 出版日期 | 2013 |
| 卷号 | 8期号:1页码:90-95 |
| 关键词 | Anti-oxidative enzymes - Cell apoptosis - Expression profile - Lipid peroxidation - Perfluorooctanoic acid - Super oxide dismutase - Zebrafish - Zebrafish embryos |
| ISSN号 | 0974-7435 |
| 产权排序 | (1) Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, China |
| 通讯作者 | Yang, S. (yshl2004@163.com) |
| 英文摘要 | Perfluorooctanoic acid (PFOA) is an organic pollutant abundant in the environment, and the potential toxicity of which is causing great concern. The oxidative and apoptotic potential of PFOA was assessed in a shortterm in vivo zebrafish assay in this study. Activities of antioxidative enzymes, including superoxide dismutase and catalase, were significantly altered in PFOA-treated embryos. Lipid peroxidation was increased with exposure to higher concentrations. Expression profiles of certain genes related to cellular apoptosis were then investigated. The expression of p53 and Baxwere partially increased, which could be linked to PFOA-induced cell apoptosis in zebrafish. The overall results demonstrated that PFOA could induce oxidative stress and alter the expression of genes involve in apoptosis, resulting in oxidative damagesin zebrafish embryos. |
| 学科主题 | Gene expression |
| 收录类别 | EI |
| 语种 | 英语 |
| 公开日期 | 2015-08-11 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/8845]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 推荐引用方式 GB/T 7714 | Yang, Shaoli,Su, Zhen. In vivo assessment of the oxidative and apoptotic potential of perfluorooctanoic acid[J]. BioTechnology: An Indian Journal,2013,8(1):90-95. |
| APA | Yang, Shaoli,&Su, Zhen.(2013).In vivo assessment of the oxidative and apoptotic potential of perfluorooctanoic acid.BioTechnology: An Indian Journal,8(1),90-95. |
| MLA | Yang, Shaoli,et al."In vivo assessment of the oxidative and apoptotic potential of perfluorooctanoic acid".BioTechnology: An Indian Journal 8.1(2013):90-95. |
入库方式： OAI收割
来源：烟台海岸带研究所
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