Mn(II)-monosubstituted polyoxometalates as candidates for contrast agents in magnetic resonance imaging
文献类型：期刊论文
| 作者 | Li, Zhongfeng; Li, Weisheng; Li, Xiaojing; Pei, Fengkui; Wang, Xuxia; Lei, Hao |
| 刊名 | JOURNAL OF INORGANIC BIOCHEMISTRY
 |
| 出版日期 | 2007-07-01 |
| 卷号 | 101期号:7页码:1036-1042 |
| 关键词 | magnetic resonance imaging contrast agent manganese polyoxometalates relaxivity |
| 英文摘要 | Two mono-substituted manganese polyoxometalates, K6MnSiW11O39 (MnSiW11) and K8MnP2W17O61 (MnP2W17), have been evaluated by in vivo and in vitro experiments as the candidates of potential tissue-specific contrast agents for magnetic resonance imaging (MRI). T-1-relaxivities of 12.1 mM(-1) s(-1) for MnSiW11 and 4.7 mM(-1) s(-1) for MnP2W17 (400 MHz, 25 degrees C) were higher than or similar to that of the commercial MRI contrast agent (GdDTPA). Their relaxivities in BSA and hTf solutions were also reported. After administration of MnSiW11 and MnP2W17 to Wistar rats, MR imaging showed longer and remarkable enhancement in rat liver and favorable renal excretion capability. The signal intensity increased by 74.0 +/- 4.9% for the liver during the whole imaging period (90 min) and by 67.2 +/- 5.3% for kidney within 20-70 min after injection at 40 +/- 3 mu mol kg(-1) dose for MnSiW11. MnP2W17 induced 71.5 +/- 15.1%. enhancement for the liver in 10-45 min range and 73.1 +/- 3.2% enhancement for kidney within 5-40 min after injection at 39 +/- 3 mu mol kg(-1) dose. In vitro and in vivo study showed MnSiW11 and MnP2W17 being favorable candidates as the tissue-specific contrast agents for MRI. (c) 2007 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | PRECLINICAL EVALUATION ; PROTON RELAXATION ; SERUM-ALBUMIN ; MRI ; COMPLEXES ; GADOLINIUM(III) ; WATER ; STABILITY ; GDDTPA ; METAL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248109800008 |
| 公开日期 | 2015-08-18 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4877]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhongfeng,Li, Weisheng,Li, Xiaojing,et al. Mn(II)-monosubstituted polyoxometalates as candidates for contrast agents in magnetic resonance imaging[J]. JOURNAL OF INORGANIC BIOCHEMISTRY,2007,101(7):1036-1042. |
| APA | Li, Zhongfeng,Li, Weisheng,Li, Xiaojing,Pei, Fengkui,Wang, Xuxia,&Lei, Hao.(2007).Mn(II)-monosubstituted polyoxometalates as candidates for contrast agents in magnetic resonance imaging.JOURNAL OF INORGANIC BIOCHEMISTRY,101(7),1036-1042. |
| MLA | Li, Zhongfeng,et al."Mn(II)-monosubstituted polyoxometalates as candidates for contrast agents in magnetic resonance imaging".JOURNAL OF INORGANIC BIOCHEMISTRY 101.7(2007):1036-1042. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。