Detection of toxoplasmic lesions in mouse brain by USPIO-enhanced magnetic resonance imaging
文献类型：期刊论文
| 作者 | Wei, Li; Zhou, Gang; Li, Zhen; He, Li; Gao, Mingyuan; Tan, Jinquan; Lei, Hao |
| 刊名 | MAGNETIC RESONANCE IMAGING
 |
| 出版日期 | 2007-12-01 |
| 卷号 | 25期号:10页码:1442-1448 |
| 关键词 | magnetic resonance imaging toxoplasmosis encephalitis USPIO mouse brain |
| 英文摘要 | The objective of this study was to examine the feasibility of detecting toxoplasmic brain lesions in a mouse model of cerebral toxoplasmosis by ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI). Toxoplasmosis encephalitis was induced in Kunming mice by intracerebral injection of Toxoplasma gondii tachyzoites. T-2- and T-2(*)-weighted MRI was performed 1, 3, 4, 5 and 6 days after infection before USPIO injection; immediately after USPIO injection; and 24 h later. A comparison of USPIO enhancement and Gd-DTPA enhancement was made in three toxoplasmic mice 4 days after infection. Hematoxylin and eosin staining and Prussian blue staining were performed to detect inflammatory reactions and presence of iron in and around the toxoplasmic brain lesions. Nonenhanced T-2-/T-2(*)-weighted imaging detected few abnormalities in the brain up to 5 days. Most mice developed prominent hydrocephalus at 6 days. Gd-DTPA-enhanced imaging showed prominent enhancement of the cerebral ventricles but revealed only few space-occupying lesions in the parenchyma. USPIO-enhanced T-2(*)-weighted imaging showed improved detection of toxoplasmic brain lesions that were invisible to nonenhanced T-2-/T-2(*)-weighted imaging and gadolinium-enhanced imaging. Most of the enhancing lesions showed nodular enhancement immediately after USPIO injection, some of which changed appearance 24 h later, having a ring enhancement at the outer rim. It can be concluded that USPIO enhancement of the toxoplasmic lesions may reflect blood-brain barrier impairment and/or inflammatory reactions associated with these lesions. USPIO-enhanced imaging may be used in combination with gadoliniumenhanced imaging to provide better characterization of toxoplasmic brain lesions and, potentially, improve the differential diagnosis of toxoplasmosis encephalitis. (c) 2007 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | SUPERPARAMAGNETIC IRON-OXIDE ; BONE-MARROW-TRANSPLANTATION ; ENCEPHALITIS ; HYDROCEPHALUS ; GONDII ; MRI ; BARRIER ; NANOPARTICLES ; INFILTRATION ; PATHOGENESIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000251488500013 |
| 公开日期 | 2015-08-18 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4887]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China 2.Wuhan Univ, Sch Med, Dept Immunol, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, Inst Phys, State Key Lab Colloid Interface Sci & Chem Thermo, Beijing 100080, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Li,Zhou, Gang,Li, Zhen,et al. Detection of toxoplasmic lesions in mouse brain by USPIO-enhanced magnetic resonance imaging[J]. MAGNETIC RESONANCE IMAGING,2007,25(10):1442-1448. |
| APA | Wei, Li.,Zhou, Gang.,Li, Zhen.,He, Li.,Gao, Mingyuan.,...&Lei, Hao.(2007).Detection of toxoplasmic lesions in mouse brain by USPIO-enhanced magnetic resonance imaging.MAGNETIC RESONANCE IMAGING,25(10),1442-1448. |
| MLA | Wei, Li,et al."Detection of toxoplasmic lesions in mouse brain by USPIO-enhanced magnetic resonance imaging".MAGNETIC RESONANCE IMAGING 25.10(2007):1442-1448. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。