The gadolinium complexes with polyoxometalates as potential MRI contrast agents
文献类型：期刊论文
| 作者 | Li, Zhongfeng; Li, Weisheng; Li, Xiaojing; Pei, Fengkui; Li, Yingxia; Lei, Hao |
| 刊名 | MAGNETIC RESONANCE IMAGING
 |
| 出版日期 | 2007-04-01 |
| 卷号 | 25期号:3页码:412-417 |
| 关键词 | magnetic resonance imaging (MRI) contrast agent gadolinium polyoxometalates relaxivity |
| 英文摘要 | The two gadolinium (Gd) polyoxometalates, K-15[Gd(BW11O39)(2)] [Gd(BW11)(2)] and K-17[Gd(CuW11O39)(2)] [Gd(CuW11)(2)] have been evaluated by in vivo and in vitro experiments as the candidates of potential tissue-specific magnetic resonance imaging (MRI) contrast agents. T-1 relaxivities of 17.12 mM(-1) . s(-1) for Gd(BW11)(2) and 19.95 mM(-1) . s(-1) for Gd(CuW11)(2) (400MHz, 25 degrees C) were much higher than that of the commercial MRI contrast agent (GdDTPA). Their relaxivities in bovine serum albumin and human serum transferrin solutions were also reported. After administration of Gd(BW11)(2) and Gd(CuW11)(2) to Wistar rats, MRI showed longer and remarkable enhancement in rat liver and favorable renal excretion capability. The signal intensity increased by 37.63 +/- 3.45% for the liver during the whole imaging period (100 min) and by 61.47 +/- 10.03% for kidney within 5-40 min after injection at 40 +/- 1-mu mol . kg(-1) dose for Gd(CuW11)(2), and Gd(BW11)(2) induced 50.44 +/- 3.51% enhancement in the liver in 5-50-min range and 61.47 +/- 10.03% enhancement for kidney within 5-40 min after injection at 39 +/- 4 mu mol . kg(-1) dose. In vitro and in vivo study showed that Gd(BW11)(2) and Gd(CuW11)(2) are favorable candidates as tissue-specific contrast agents for MRI. (c) 2007 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | RELAXATION ; WATER ; STABILITY ; QUALITY ; GDDTPA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000245614500017 |
| 公开日期 | 2015-08-18 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4888]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 10039, Peoples R China 3.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhongfeng,Li, Weisheng,Li, Xiaojing,et al. The gadolinium complexes with polyoxometalates as potential MRI contrast agents[J]. MAGNETIC RESONANCE IMAGING,2007,25(3):412-417. |
| APA | Li, Zhongfeng,Li, Weisheng,Li, Xiaojing,Pei, Fengkui,Li, Yingxia,&Lei, Hao.(2007).The gadolinium complexes with polyoxometalates as potential MRI contrast agents.MAGNETIC RESONANCE IMAGING,25(3),412-417. |
| MLA | Li, Zhongfeng,et al."The gadolinium complexes with polyoxometalates as potential MRI contrast agents".MAGNETIC RESONANCE IMAGING 25.3(2007):412-417. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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