Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells
文献类型：期刊论文
| 作者 | Efferth, Thomas1; Kah, Stefan2,3,6; Paulus, Kerstin4; Adams, Michael2; Rauh, Rolf5; Boechzelt, Herbert3; Hao, Xiaojiang6 ; Kaina, Bernd5; Bauer, Rudolf2
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| 刊名 | MOLECULAR CANCER THERAPEUTICS
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| 出版日期 | 2008 |
| 卷号 | 7期号:1页码:152-161 |
| 英文摘要 | The cure from cancer is still not a reality for all patients, which is mainly due to the limitations of chemotherapy (e.g., drug resistance and toxicity). Apart from the high-throughput screening of synthetic chemical libraries, natural products represent attractive alternatives for drug development. We have done a systematic bioactivity-based screening of natural products derived from medicinal plants used in traditional Chinese medicine. Plant extracts with growth-inhibitory activity against tumor cells have been fractionated by chromatographic techniques. We have isolated the bioactive compounds and elucidated the chemical structures by nuclear magnetic resonance and mass spectrometry. By this strategy, we identified 25-O-acetyl-23,24-dihydro-cucurbitacin F as a cytotoxic constituent of Quisqualis indica. Another promising compound identified by this approach was miltirone from Salvia miltiorrhiza. The IC50 values for miltirone of 60 National Cancer Institute cell lines were associated with the micro-array-based expression of 9,706 genes. By COMPARE and hierarchical cluster analyses, candidate genes were identified, which significantly predicted sensitivity or resistance of cell lines to miltirone. |
| 类目[WOS] | Oncology |
| 研究领域[WOS] | Oncology |
| 关键词[WOS] | GENE-EXPRESSION PATTERNS ; TETRAZOLIUM ASSAY ; CANCER ; LINES ; APOPTOSIS ; DRUGS ; THERAPY ; PROTEIN ; SRG3 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000252580900016 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/23874]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.German Canc Res Ctr, D-69120 Heidelberg, Germany 2.Graz Univ, Inst Pharmaceut Sci, A-8010 Graz, Austria 3.Joanneum Res, Graz, Austria 4.Univ Dusseldorf, Inst Pharmaceut Biol, Dusseldorf, Germany 5.Johannes Gutenberg Univ Mainz, Inst Toxicol, D-6500 Mainz, Germany 6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Efferth, Thomas,Kah, Stefan,Paulus, Kerstin,et al. Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells[J]. MOLECULAR CANCER THERAPEUTICS,2008,7(1):152-161. |
| APA | Efferth, Thomas.,Kah, Stefan.,Paulus, Kerstin.,Adams, Michael.,Rauh, Rolf.,...&Bauer, Rudolf.(2008).Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells.MOLECULAR CANCER THERAPEUTICS,7(1),152-161. |
| MLA | Efferth, Thomas,et al."Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells".MOLECULAR CANCER THERAPEUTICS 7.1(2008):152-161. |
入库方式： OAI收割
来源：昆明植物研究所
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