Cytotoxic ent-kaurane diterpenoids from Isodon macrophyllus
文献类型：期刊论文
| 作者 | Zhang, Ji-Xia1; He, Zhi-An1; Chen, Zheng-Yue1; Wang, Yong-Xue1; Bai, Su-Ping1; Sun, Han-Dong2
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| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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| 出版日期 | 2009 |
| 卷号 | 11期号:8页码:693-697 |
| 关键词 | Isodon macrophyllus ent-kauranoids diterpene dayecrystals D-E cytotoxicity |
| 英文摘要 | Two new ent-kaurane diterpenoids, dayecrystals D-E (1-2), together with nine known compounds, isojaponin A (3), rabdosin A (4), lushanrubescensin J (5), wikstroemioidin B (6), maoyecrystal C (7), rabdosin B (8), isodonal (9), shikokianin (10), and effusanin A (11), were isolated from the leaves of Isodon macrophyllus. The structures of the new compounds were elucidated using 1D and 2D NMR spectroscopy. The (13)C-NMR spectral data of compound 4 are reported for the first time. All of the compounds were tested for their cytotoxicities against DU145 and LoVo human tumor cells. Compounds 4, 10, and 11 showed inhibitory effects on DU145 cells with IC(50) values 5.90, 4.24, and 3.16 mu M, and LoVo cells with IC(50) values 14.20, 17.55, and 3.02 mu M, respectively. |
| 类目[WOS] | Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000268666300002 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/23878]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Xinxiang Med Univ, Pharmaceut Lab, Xinxiang, Henan Province, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ji-Xia,He, Zhi-An,Chen, Zheng-Yue,et al. Cytotoxic ent-kaurane diterpenoids from Isodon macrophyllus[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2009,11(8):693-697. |
| APA | Zhang, Ji-Xia,He, Zhi-An,Chen, Zheng-Yue,Wang, Yong-Xue,Bai, Su-Ping,&Sun, Han-Dong.(2009).Cytotoxic ent-kaurane diterpenoids from Isodon macrophyllus.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,11(8),693-697. |
| MLA | Zhang, Ji-Xia,et al."Cytotoxic ent-kaurane diterpenoids from Isodon macrophyllus".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 11.8(2009):693-697. |
入库方式： OAI收割
来源：昆明植物研究所
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