Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in cultured cortical neurons
文献类型：期刊论文
| 作者 | Zhu, Judy T. T.1; Choi, Roy C. Y.1; Xie, Heidi Q.1; Zheng, Ken Y. Z.1; Guo, Ava J. Y.1; Bi, Cathy W. C.1; Lau, David T. W.1; Li, Jun1; Dong, Tina T. X.1; Lau, Brad W. C.2 |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2009-09-11 |
| 卷号 | 461期号:2页码:172-176 |
| 关键词 | Neuroprotection Cortical neuron Flavonoid Hibifolin |
| 英文摘要 | The toxicity of aggregated P-amyloid (A beta) has been implicated as a critical cause in the development of Alzheimer's disease (AD). Hibifolin, a flavonol glycoside derived from herbal plants, possessed a strong protective activity against cell death induced by aggregated A beta. Application of hibifolin in primary cortical neurons prevented the A beta-induced cell death in a dose-dependent manner. In cultured cortical neurons. the pre-treatment of hibifolin abolished A beta-induced Ca(2+) mobilization, and also reduced A beta-induced caspase-3 and caspase-7 activation. Moreover, DNA fragmentation induced by A beta could be suppressed by hibifolin. In addition to such protection mechanisms, hibifolin was able to induce Akt phosphorylation in cortical neurons, which could be another explanation for the neuroprotection activity. These results therefore provided the first evidence that hibifolin protected neurons against A beta-induced apoptosis and stimulated Akt activation, which would be useful in developing potential drugs or food supplements for treating AD. (C) 2009 Elsevier Ireland Ltd. All rights reserved. |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | ALZHEIMERS-DISEASE ; IN-VIVO ; INDUCED TOXICITY ; KINASE-B ; APOPTOSIS ; ESTROGEN ; CELLS ; ACETYLCHOLINESTERASE ; NEUROPROTECTION ; PHYTOESTROGENS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000268429400024 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/23881]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Hong Kong Univ Sci & Technol, Dept Biol, Kowloon, Hong Kong, Peoples R China 2.Macao Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, Taipa, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Judy T. T.,Choi, Roy C. Y.,Xie, Heidi Q.,et al. Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in cultured cortical neurons[J]. NEUROSCIENCE LETTERS,2009,461(2):172-176. |
| APA | Zhu, Judy T. T..,Choi, Roy C. Y..,Xie, Heidi Q..,Zheng, Ken Y. Z..,Guo, Ava J. Y..,...&Tsim, Karl W. K..(2009).Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in cultured cortical neurons.NEUROSCIENCE LETTERS,461(2),172-176. |
| MLA | Zhu, Judy T. T.,et al."Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in cultured cortical neurons".NEUROSCIENCE LETTERS 461.2(2009):172-176. |
入库方式： OAI收割
来源：昆明植物研究所
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