Effects of three diterpenoids on tumour cell proliferation and telomerase activity
文献类型：期刊论文
| 作者 | Yang, Yunshan1 ; Sun, Handong2; Zhou, Yiping1; Ji, Shuyu1; Li, Malin1
|
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2009 |
| 卷号 | 23期号:11页码:1007-1012 |
| 关键词 | XB MB EB cell proliferation telomerase activity |
| 英文摘要 | Xerophilusin B (XB), macrocalin B (MB) and eriocalyxin B (EB) belong to ent-kaurene diterpenoids. The inhibition effects of three ent-kaurane compounds on the proliferation of six tumour lines (K562, HL-60, A549, MKN, HCT and CA) were estimated by methyl-thiazol-tetrazolium, and the telomerase activity in K562 cells was measured by the telomeric repeat amplification protocol-enzyme-linked immunosorbent assay. We found that XB, MB and EB could significantly inhibit the proliferation of tumour cells. Within the concentration range of 10-4-10-8 mol L-1, three ent-kaurane compounds could markedly inhibit the telomerase activity in K562 cells, and their effects on telomerase were exhibited in a dose-dependent manner. Our results demonstrate that XB, MB and EB can inhibit the proliferation of tumour cells and the telomerase activity, which provides data for developing ent-compounds as antitumour drugs. |
| 类目[WOS] | Chemistry, Applied ; Chemistry, Medicinal |
| 研究领域[WOS] | Chemistry ; Pharmacology & Pharmacy |
| 关键词[WOS] | ENT-KAURENE DITERPENOIDS ; ANTITUMOR-ACTIVITY ; IN-VITRO ; ISODON ; TERPENOIDS ; CISPLATIN ; CANCER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000266918100005 |
| 公开日期 | 2015-08-18 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/23882]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yunshan,Sun, Handong,Zhou, Yiping,et al. Effects of three diterpenoids on tumour cell proliferation and telomerase activity[J]. NATURAL PRODUCT RESEARCH,2009,23(11):1007-1012. |
| APA | Yang, Yunshan,Sun, Handong,Zhou, Yiping,Ji, Shuyu,&Li, Malin.(2009).Effects of three diterpenoids on tumour cell proliferation and telomerase activity.NATURAL PRODUCT RESEARCH,23(11),1007-1012. |
| MLA | Yang, Yunshan,et al."Effects of three diterpenoids on tumour cell proliferation and telomerase activity".NATURAL PRODUCT RESEARCH 23.11(2009):1007-1012. |
入库方式： OAI收割
来源：昆明植物研究所
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