Cytotoxic and Antioxidative Phenolic Compounds from the Traditional Chinese Medicinal Plant, Myristica fragrans
文献类型：期刊论文
| 作者 | Duan, Lin1; Tao, Hong-Wen1; Hao, Xiao-Jiang2 ; Gu, Qian-Qun1; Zhu, Wei-Ming1
|
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2009-09-01 |
| 卷号 | 75期号:11页码:1241-1245 |
| 关键词 | Myristica fragrans Myristicaceae cytotoxicity antioxidative activity phenylpropanoids |
| 英文摘要 | Two new phenolic compounds were isolated from the fruits of Myristica fragrans and their structures were elucidated as (-)-1-(2,6-dihydroxyphenyl)-9-[4-hydroxy-3-(p-menth-1-en-8-oxy)phenyl]-1-nonanone (1) and (7R,8R)-7,8-dihydro-7-(3,4-dihydroxyphenyl)-3'-methoxy-8- methyl-1'-(E-propenyl)benzofuran (2). In addition, the absolute configuration of (+)-Delta 8'-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan (3) was determined for the first time through spectroscopic and chemical methods. Their antioxidative activities against 2,2-diphenyl-1-picrylhydrazyl radical and cytotoxicity against K-562 cells were tested, and (7S,8S,7'R,8'S)-4,5'-diliydroxy-3,3'-dimethoxy-7,7'-epoxylignan (4) showed the corresponding activities with IC(50) values of 39.4 and 2.11 mu M, respectively. |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | ENANTIOSELECTIVE SYNTHESIS ; ABSOLUTE-CONFIGURATION ; MACE ; NEOLIGNANS ; PHENYLPROPANOIDS ; PREVENTION ; ASSIGNMENT ; COMPONENTS ; ARIL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000270401600012 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/23889]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Duan, Lin,Tao, Hong-Wen,Hao, Xiao-Jiang,et al. Cytotoxic and Antioxidative Phenolic Compounds from the Traditional Chinese Medicinal Plant, Myristica fragrans[J]. PLANTA MEDICA,2009,75(11):1241-1245. |
| APA | Duan, Lin,Tao, Hong-Wen,Hao, Xiao-Jiang,Gu, Qian-Qun,&Zhu, Wei-Ming.(2009).Cytotoxic and Antioxidative Phenolic Compounds from the Traditional Chinese Medicinal Plant, Myristica fragrans.PLANTA MEDICA,75(11),1241-1245. |
| MLA | Duan, Lin,et al."Cytotoxic and Antioxidative Phenolic Compounds from the Traditional Chinese Medicinal Plant, Myristica fragrans".PLANTA MEDICA 75.11(2009):1241-1245. |
入库方式： OAI收割
来源：昆明植物研究所
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