Gastrodia elata modulates amyloid precursor protein cleavage and cognitive functions in mice
文献类型：期刊论文
| 作者 | Mishra, Manisha1,2; Huang, Junjie2; Lee, Yin Yeng2; Chua, Doreen See Kin2; Lin, Xiaoyan2; Hu, Jiang-Miao3 ; Heese, Klaus1,2
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| 刊名 | BIOSCIENCE TRENDS
 |
| 出版日期 | 2011 |
| 卷号 | 5期号:3页码:129-138 |
| 关键词 | Alzheimer's disease beta-Amyloid precursor protein Kampo Neurodegeneration traditional Chinese medicine |
| 英文摘要 | Gastrodia elata (Tianma) is a traditional Chinese medicine often used for the treatment of headache, convulsions, hypertension, and cardiovascular diseases. The vasodilatory actions of Tianma led us to investigate its specific effects on memory and learning as well as on Alzheimer's disease (AD)-related signaling. We conducted a radial arm water maze analysis and the novel object recognition test to assess the cognitive functions of Tianma-treated mice. Our data show that Tianma enhances cognitive functions in mice. Further investigations revealed that Tianma enhances the alpha-secretase-mediated proteolytic processing of the amyloid precursor protein (App) that precludes the amyloid-beta peptide production and supports the non-amyloidogenic processing of App which is favorable in AD treatment. We hypothesize that Tianma promotes cognitive functions and neuronal survival by inhibiting beta-site App-cleaving enzyme 1 activity and promoting the neuroprotective alpha-secretase activity. |
| 类目[WOS] | Biology |
| 研究领域[WOS] | Life Sciences & Biomedicine - Other Topics |
| 关键词[WOS] | ALZHEIMERS-DISEASE ; HUPERZINE-A ; OBJECT RECOGNITION ; ETHER FRACTION ; NEURONAL DIFFERENTIATION ; THERAPEUTIC TARGETS ; MEMORY ACQUISITION ; METHANOL EXTRACTS ; CHINESE MEDICINE ; NATURAL-PRODUCTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000301180300007 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/23945]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Nanyang Technol Univ, Sch Biol Sci, Coll Sci, Dept Mol & Cell Biol, Singapore 637551, Singapore 2.Nanyang Technol Univ, Inst Adv Studies, Singapore 637551, Singapore 3.Chinese Acad Sci, Kunming Inst Bot, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mishra, Manisha,Huang, Junjie,Lee, Yin Yeng,et al. Gastrodia elata modulates amyloid precursor protein cleavage and cognitive functions in mice[J]. BIOSCIENCE TRENDS,2011,5(3):129-138. |
| APA | Mishra, Manisha.,Huang, Junjie.,Lee, Yin Yeng.,Chua, Doreen See Kin.,Lin, Xiaoyan.,...&Heese, Klaus.(2011).Gastrodia elata modulates amyloid precursor protein cleavage and cognitive functions in mice.BIOSCIENCE TRENDS,5(3),129-138. |
| MLA | Mishra, Manisha,et al."Gastrodia elata modulates amyloid precursor protein cleavage and cognitive functions in mice".BIOSCIENCE TRENDS 5.3(2011):129-138. |
入库方式： OAI收割
来源：昆明植物研究所
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