Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product confluentin
文献类型：期刊论文
| 作者 | Hellwig, V; Nopper, R; Mauler, F; Freitag, J; Liu, JK; Ding, ZH; Stadler, M |
| 刊名 | ARCHIV DER PHARMAZIE
 |
| 出版日期 | 2003-04-01 |
| 卷号 | 336期号:2页码:119-126 |
| 关键词 | basidiomycetes pain scutigeral neogrifolin grifolin albaconol |
| 英文摘要 | Several prenylphenols from basidiocarps of European and Chinese Albatrellus spp., namely grifolin (1), neogrifolin (2), confluentin (3), scutigeral (4), and albaconol (5) were investigated concerning their activities in test models for vanilloid receptor modulation. The isolation of these compounds from A. confluens and structure elucidation of the novel natural product confluentin (3) are described. The effects of scutigeral and neogrifolin on vanilloid receptors were studied by means of electrophysiological methodology on rat dorsal root ganglion neurons as well as on recombinant cell lines expressing the rat VR1 receptor. Concurrently, the effects of compounds 1-5 on a reporter cell line expressing the human vanilloid receptor VR1 were measured. In contrast to previous studies reported in the literature, the results of these investigations suggest that fungal prenylphenols act as weak antagonists (activity in the muM range), rather than exhibiting agonistic activities. |
| 类目[WOS] | Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Chemistry |
| 关键词[WOS] | OVINUS ; MUSHROOM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000182734400005 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/23980]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.PH R EU ET Nat Prod, Pharma Res Ctr Wuppertal, Bayer Hlth Care, D-42096 Wuppertal, Germany 2.CNS Res, Pharma Res Ctr Wuppertal, Bayer Hlth Care, Wuppertal, Germany 3.Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hellwig, V,Nopper, R,Mauler, F,et al. Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product confluentin[J]. ARCHIV DER PHARMAZIE,2003,336(2):119-126. |
| APA | Hellwig, V.,Nopper, R.,Mauler, F.,Freitag, J.,Liu, JK.,...&Stadler, M.(2003).Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product confluentin.ARCHIV DER PHARMAZIE,336(2),119-126. |
| MLA | Hellwig, V,et al."Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product confluentin".ARCHIV DER PHARMAZIE 336.2(2003):119-126. |
入库方式： OAI收割
来源：昆明植物研究所
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