GABA Attenuates Amyloid Toxicity by Downregulating its Endocytosis and Improves Cognitive Impairment
文献类型：期刊论文
| 作者 | Sun, Xiaqin1; Meng, Xiaolu4 ; Zhang, Jie5; Li, Yonghui4; Wang, Liping5; Qin, Xiaoyan2,3; Sui, Nan4; Zhang, Yan1
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| 刊名 | JOURNAL OF ALZHEIMERS DISEASE
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| 出版日期 | 2012 |
| 卷号 | 31期号:3页码:635-649 |
| 关键词 | Amyloid-beta cell death cognitive impairment endocytosis GABA |
| ISSN号 | 1387-2877 |
| 产权排序 | 3 |
| 通讯作者 | Zhang, Y (reprint author), Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Room 219, Beijing 100871, Peoples R China. |
| 英文摘要 | GABA (gamma-aminobutyric acid) receptor modulators have been investigated as a potential treatment strategy in Alzheimer's disease (AD). In the present study, we found that GABA levels were different in wild type (WT) and A beta PP/PS1 mouse brains. GABA downregulated amyloid-beta (A beta) uptake in neurons through the receptor for advanced glycation end-products. Therefore, relative high levels of GABA decreased cytotoxicity induced by A beta in WT mice. GABA treatment decreased basal levels of cell death and the cell death induced by hydrogen peroxide in WT and A beta PP/PS1 neurons. Application of GABA during early life before 2 months of age can improve cognitive function significantly in A beta PP/PS1 mice. However, GABA treatment at 6 and 8 months of age cannot improve water maze performance. Activating or suppressing GABA(A) receptors by optogenetic methods also confirmed that GABA activation before 2 months of age increased water maze performance in A beta PP/PS1 mice. Our data suggest that GABA administration during early life can be a potential treatment for AD. |
| 学科主题 | Cognitive psychology,Medical psychology |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the National Program of Basic Research sponsored by the Ministry of Science and Technology of China (2009CB941301), National Science Foundation of China (NSFC) Major Research Grant (91132718), Roche Research Grant, Peking University President Research Grant and Ministry of Education Recruiting Research Grant to YZ, 973 Program (2009CB522002) to NS, National Natural Science Foundation China (31170988) to NS, 985 project (MUC98504-1, MUC98507-08) to XQ, "Hundred Talents Program" and the Instrument Developing Project of the Chinese Academy of Sciences (Grant No. 2010019) to LW. |
| 原文出处 | http://iospress.metapress.com/content/krw8776488073240/fulltext.pdf |
| 语种 | 英语 |
| WOS记录号 | WOS:000308197000016 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/12827]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China 2.Minzu Univ China, Coll Life & Environm Sci, Biotechnol Lab, Beijing, Peoples R China 3.Minzu Univ China, Coll Life & Environm Sci, State Key Lab Chinese Ethn Minor Tradit Med, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 5.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen Key Lab Neuropsychiat Modulat, Shenzhen, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Xiaqin,Meng, Xiaolu,Zhang, Jie,et al. GABA Attenuates Amyloid Toxicity by Downregulating its Endocytosis and Improves Cognitive Impairment[J]. JOURNAL OF ALZHEIMERS DISEASE,2012,31(3):635-649. |
| APA | Sun, Xiaqin.,Meng, Xiaolu.,Zhang, Jie.,Li, Yonghui.,Wang, Liping.,...&Zhang, Yan.(2012).GABA Attenuates Amyloid Toxicity by Downregulating its Endocytosis and Improves Cognitive Impairment.JOURNAL OF ALZHEIMERS DISEASE,31(3),635-649. |
| MLA | Sun, Xiaqin,et al."GABA Attenuates Amyloid Toxicity by Downregulating its Endocytosis and Improves Cognitive Impairment".JOURNAL OF ALZHEIMERS DISEASE 31.3(2012):635-649. |
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来源：心理研究所
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