Ethanol-induced hepatic steatosis is modulated by glycogen level in the liver
文献类型：期刊论文
| 作者 | Gu, Jin; Zhang, Yongxian（张永贤）; Xu, Daqian; Zhao, Zilong; Zhang, Yuxue; Pan, Yi（潘怡）; Cao, Peijuan; Wang, ZhenZhen（王甄真）; Chen, Yan（陈雁）
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| 刊名 | JOURNAL OF LIPID RESEARCH
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| 出版日期 | 2015 |
| 卷号 | 56期号:7页码:1329-1339 |
| 关键词 | alcoholic liver disease fatty liver lipid metabolism glycogen synthase sterol regulatory element-binding protein |
| 英文摘要 | Alcoholic liver disease (ALD) is a major health problem worldwide and hepatic steatosis is an early response to alcohol consumption. Fat and glycogen are two major forms of energy storage in the liver; however, whether glycogen metabolism in the liver impacts alcohol-induced steatosis has been elusive. In this study, we used a mouse model with overexpression of PPP1R3G in the liver to dissect the potential role of glycogen on alcohol-induced fatty liver formation. PPP1R3G is a regulatory subunit of protein phosphatase 1 and stimulates glycogenesis in the liver. Chronic and binge ethanol (EtOH) feeding reduced glycogen level in the mouse liver and such inhibitory effect of EtOH was reversed by PPP1R3G overexpression. In addition, PPP1R3G overexpression abrogated EtOH-induced elevation of serum levels of alanine aminotransferase and aspartate aminotransferase, increase in liver triglyceride concentration, and lipid deposition in the liver. EtOH-stimulated sterol regulatory element-binding protein (SREBP)1c, a master regulator of lipogenesis, was also reduced by PPP1R3G overexpression in vivo. In AML-12 mouse hepatocytes, PPP1R3G overexpression could relieve EtOH-induced lipid accumulation and SREBP-1c stimulation. In conclusion, our data indicate that glycogen metabolism is closely linked to EtOH-induced liver injury and fatty liver formation. |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | ELEMENT-BINDING PROTEIN ; DISEASE PATHOGENESIS ; GLUCOSE-HOMEOSTASIS ; LIPID-METABOLISM ; FATTY LIVER ; ACTIVATION ; SREBP ; PHOSPHATASE-1 ; PATHWAYS ; SUBUNIT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356834700010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/52]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Gu, Jin,Zhang, Yongxian,Xu, Daqian,et al. Ethanol-induced hepatic steatosis is modulated by glycogen level in the liver[J]. JOURNAL OF LIPID RESEARCH,2015,56(7):1329-1339. |
| APA | Gu, Jin.,Zhang, Yongxian.,Xu, Daqian.,Zhao, Zilong.,Zhang, Yuxue.,...&Chen, Yan.(2015).Ethanol-induced hepatic steatosis is modulated by glycogen level in the liver.JOURNAL OF LIPID RESEARCH,56(7),1329-1339. |
| MLA | Gu, Jin,et al."Ethanol-induced hepatic steatosis is modulated by glycogen level in the liver".JOURNAL OF LIPID RESEARCH 56.7(2015):1329-1339. |
入库方式： OAI收割
来源：上海营养与健康研究所
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