Nickel exposure is associated with the prevalence of type 2 diabetes in Chinese adults
文献类型：期刊论文
| 作者 | Liu, Gang; Sun, Liang（孙亮）; Pan, An; Zhu, Mingjiang; Li, Zi; Wang, ZhenZhen（王甄真）; Liu, Xin; Ye, Xingwang; Li, Huaixing（黎怀星）; Zheng, He |
| 刊名 | INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 44期号:1页码:240-248 |
| 关键词 | Nickel exposure epidemiology type 2 diabetes |
| 英文摘要 | Background: Nickel exposure can induce hyperglycaemia in rodents, but little is known about its association with abnormal glucose metabolism in humans. We aimed to investigate the association of nickel exposure with the prevalence of type 2 diabetes in Chinese adults. Methods: A total of 2115 non-institutionalized men and women aged 55 to 76 years from Beijing and Shanghai were included, and urinary nickel concentration was assessed by inductively coupled plasma mass spectroscopy. The prevalence of type 2 diabetes was compared across urinary nickel quartiles. Fasting plasma glucose, insulin, lipids, C-reactive protein and glycated haemoglobin A1c, as well as urinary albumin and creatinine were measured. Results: The median concentration of urinary nickel was 3.63 mu g/l (interquartile range: 2.29-5.89 mu g/l), and the prevalence of diabetes was 35.3% (747 cases/2115 persons). Elevated levels of urinary nickel were associated with higher fasting glucose, glycated haemoglobin A1c, insulin and homeostatic model assessment of insulin resistance (all P<0.01). The odds ratios (95% confidence interval) for diabetes across the increasing urinary nickel quartiles were 1.27 (0.97-1.67), 1.78 (1.36-2.32) and 1.68 (1.29-2.20), respectively (referencing to 1.00), after multivariate adjustment including lifestyle factors, body mass index and family history of diabetes (P for trend <0.001). The association remained unchanged after further controlling for urinary creatinine and C-reactive protein (P for trend <0.001). Conclusions: Increased urinary nickel concentration is associated with elevated prevalence of type 2 diabetes in humans. |
| 类目[WOS] | Public, Environmental & Occupational Health |
| 关键词[WOS] | IMPAIRED FASTING GLUCOSE ; REFERENCE VALUES ; INDUCED HYPERGLYCEMIA ; METABOLIC SYNDROME ; ARSENIC EXPOSURE ; DOSE-RESPONSE ; OLDER CHINESE ; URINE ; POPULATION ; TOXICOLOGY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350864200031 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/54]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 中国科学院上海生命科学研究院营养科学研究所_脂肪酸代谢与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Liu, Gang,Sun, Liang,Pan, An,et al. Nickel exposure is associated with the prevalence of type 2 diabetes in Chinese adults[J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,2015,44(1):240-248. |
| APA | Liu, Gang.,Sun, Liang.,Pan, An.,Zhu, Mingjiang.,Li, Zi.,...&Chen, Yan.(2015).Nickel exposure is associated with the prevalence of type 2 diabetes in Chinese adults.INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,44(1),240-248. |
| MLA | Liu, Gang,et al."Nickel exposure is associated with the prevalence of type 2 diabetes in Chinese adults".INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 44.1(2015):240-248. |
入库方式： OAI收割
来源：上海营养与健康研究所
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