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Luteolin Alleviates Alcoholic Liver Disease Induced by Chronic and Binge Ethanol Feeding in Mice
文献类型：期刊论文
| 作者 | Liu, Gaigai; Zhang, Yuxue; Liu, Chunchun; Xu, Daqian; Zhang, Rui; Cheng, Yuan; Pan, Yi（潘怡）; Huang, Cheng; Chen, Yan（陈雁）
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| 刊名 | JOURNAL OF NUTRITION
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| 出版日期 | 2014 |
| 卷号 | 144期号:7页码:1009-1015 |
| 英文摘要 | Ethanol consumption can lead to hepatic steatosis that contributes to late-stage liver diseases such as cirrhosis and hepatocellular carcinoma. In this study, we investigated the potential protective effect of a flavonoid, luteolin, on ethanol-induced fatty liver development and liver injury. Six-wk-old male C57BL/6 mice were divided into 3 groups: a control group; a group exposed to alcohol by using a chronic and binge ethanol feeding protocol (EtOH); and a group that was administered daily 50 mg/kg of luteolin in addition to ethanol exposure (EtOH + Lut). A chronic and binge ethanol feeding protocol was used, including chronic ethanol consumption (1%, 2%, and 4% for 3 d, and 5% for 9 d) and a binge (30% ethanol) on the last day. Compared with the control group, the EtOH group had a significant elevation in serum concentrations of alanine aminotransferase (ALT) (561%), triglyceride (TG) (47%), and LDL cholesterol (95%), together with lipid accumulation in the, liver. Compared with the EtOH group, the EtOH + Lut group had significant reductions in serum concentrations of ALT (43%), TG (22%), LDL cholesterol (52%), and lipid accumulation in the liver. Ethanol elevated liver expression of lipogenic genes including sterol regulatory element-binding protein 1c (Srebp1c) (560%), fatty acid synthase (Fasn) (190%), acetylCoA carboxylase (Acc) (48%), and stearoyl-CoA desaturase 1 (Scd1) (286%). Luteolin reduced ethanol-induced expression of these genes in the liver: Srebp1c (79%), Fasn (80%), Acc (60%), and Scd1 (89%). In cultured hepatocytes, luteolin prevented alcohol-induced lipid accumulation and increase in the expression of lipogenic genes. The transcriptional activity of the master regulator of lipid synthesis, sterol regulatory element-binding protein (SREBP), was enhanced by ethanol treatment (160%) and reduced by luteolin administration (67%). In addition, ethanol-induced reduction of AMP-activated protein kinase and SREBP-1c phosphorylation was abrogated by luteolin. Collectively, our study indicates that luteolin is effective in ameliorating ethanol-induced hepatic steatosis and injury. |
| 类目[WOS] | Nutrition & Dietetics |
| 关键词[WOS] | ACTIVATED PROTEIN-KINASE ; FATTY-ACID SYNTHESIS ; GENE-EXPRESSION ; HEPATIC STEATOSIS ; LIPID-METABOLISM ; STEATOHEPATITIS ; INTERLEUKIN-22 ; PHOSPHORYLATES ; TRANSCRIPTION ; CHOLESTEROL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337984200003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/55]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Liu, Gaigai,Zhang, Yuxue,Liu, Chunchun,et al. Luteolin Alleviates Alcoholic Liver Disease Induced by Chronic and Binge Ethanol Feeding in Mice[J]. JOURNAL OF NUTRITION,2014,144(7):1009-1015. |
| APA | Liu, Gaigai.,Zhang, Yuxue.,Liu, Chunchun.,Xu, Daqian.,Zhang, Rui.,...&Chen, Yan.(2014).Luteolin Alleviates Alcoholic Liver Disease Induced by Chronic and Binge Ethanol Feeding in Mice.JOURNAL OF NUTRITION,144(7),1009-1015. |
| MLA | Liu, Gaigai,et al."Luteolin Alleviates Alcoholic Liver Disease Induced by Chronic and Binge Ethanol Feeding in Mice".JOURNAL OF NUTRITION 144.7(2014):1009-1015. |
入库方式： OAI收割
来源：上海营养与健康研究所
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