热门
Regulation of Glucose Homeostasis and Lipid Metabolism by PPP1R3G-mediated Hepatic Glycogenesis
文献类型：期刊论文
| 作者 | Zhang, Yongxian（张永贤）; Xu, Daqian; Huang, Heng; Chen, Susie; Wang, Lingdi; Zhu, Lu; Jiang, Xiaomeng; Ruan, Xiangbo; Luo, Xiaolin; Cao, Peijuan |
| 刊名 | MOLECULAR ENDOCRINOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 28期号:1页码:116-126 |
| 英文摘要 | Liver glycogen metabolism plays an important role in glucose homeostasis. Glycogen synthesis is mainly regulated by glycogen synthase that is dephosphorylated and activated by protein phosphatase 1 (PP1) in combination with glycogen-targeting subunits or G subunits. There are seven G subunits (PPP1R3A to G) that control glycogenesis in different organs. PPP1R3G is a recently discovered G subunit whose expression is changed along the fasting-feeding cycle and is proposed to play a role in postprandial glucose homeostasis. In this study, we analyzed the physiological function of PPP1R3G using a mouse model with liver-specific overexpression of PPP1R3G. PPP1R3G overexpression increases hepatic glycogen accumulation, stimulates glycogen synthase activity, elevates fasting blood glucose level, and accelerates postprandial blood glucose clearance. In addition, the transgenic mice have a reduced fat composition, together with decreased hepatic triglyceride level. Fasting-induced hepatic steatosis is relieved by PPP1R3G overexpression. In addition, PPP1R3G overexpression is able to elevate glycogenesis in primary hepatocytes. The glycogen-binding domain is indispensable for the physiological activities of PPP1R3G on glucose metabolism and triglyceride accumulation in the liver. Cumulatively, these data indicate that PPP1R3G plays a critical role in postprandial glucose homeostasis and liver triglyceride metabolism via its regulation on hepatic glycogenesis. |
| 类目[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | PROTEIN PHOSPHATASE 1 ; TARGETING SUBUNIT ; INSULIN-RESISTANCE ; LIVER ; MUSCLE ; SYNTHASE ; PHOSPHORYLATION ; IDENTIFICATION ; BINDING ; KINASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000331799300010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/56]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, Yongxian,Xu, Daqian,Huang, Heng,et al. Regulation of Glucose Homeostasis and Lipid Metabolism by PPP1R3G-mediated Hepatic Glycogenesis[J]. MOLECULAR ENDOCRINOLOGY,2014,28(1):116-126. |
| APA | Zhang, Yongxian.,Xu, Daqian.,Huang, Heng.,Chen, Susie.,Wang, Lingdi.,...&Chen, Yan.(2014).Regulation of Glucose Homeostasis and Lipid Metabolism by PPP1R3G-mediated Hepatic Glycogenesis.MOLECULAR ENDOCRINOLOGY,28(1),116-126. |
| MLA | Zhang, Yongxian,et al."Regulation of Glucose Homeostasis and Lipid Metabolism by PPP1R3G-mediated Hepatic Glycogenesis".MOLECULAR ENDOCRINOLOGY 28.1(2014):116-126. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。